Multiple interfaces to recognize nucleosomal targets
Multiple interfaces to recognize nucleosomal targets
复制标题
识别核小体靶标的多个接口
DOI：
10.1093/jb/mvab139
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Jun-ichi Nakayama
中科院分区：
文献类型：
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作者：
Rinko Nakamura;Jun-ichi Nakayama
在真核细胞中，DNA像染色质一样紧密紧密。染色质状态必须动态改变，以增加转录因子（tf）对染色质的可及性，或通过称为异染色质的高阶染色质结构稳定地沉默基因。染色质的调控需要多种蛋白质的协同作用。tf与靶DNA的特异性结合是染色质调控的第一步，并促进组蛋白尾部翻译后修饰的变化，组蛋白尾部本身被一组组蛋白解读蛋白识别。最近的生化研究表明，一些识别特定DNA序列的tf也可以与组蛋白相互作用。此外，识别特定组蛋白尾部修饰的组蛋白解读蛋白已被证明具有直接与DNA结合的能力。在这篇评论中，我们介绍了染色质调节因子如何识别核小体靶标的最新进展。
In eukaryotic cells, DNA is tightly compacted as chromatin. Chromatin states must be dynamically changed to increase the accessibility of transcription factors (TFs) to chromatin or to stably silence genes by higher-order chromatin structures known as heterochromatin. The regulation of chromatin needs cooperative action performed by a variety of proteins. Specific binding of TFs to target DNA is the initial step of chromatin regulation and promotes changes in the post-translational modifications of histone tails, which themselves are recognized by a set of histone reader proteins. Recent biochemical studies have revealed that some TFs that recognize specific DNA sequences can also interact with histones. Furthermore, histone reader proteins that recognize specific histone tail modifications have been shown to have the ability to directly bind to DNA. In this commentary, we introduce recent advances in the elucidation of how chromatin regulating factors recognize nucleosomal targets.