Dietary fatty acid intakes and the risk of ovulatory infertility
Dietary fatty acid intakes and the risk of ovulatory infertility
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DOI：
10.1093/ajcn/85.1.231
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发表时间：
2007-01-01
影响因子：
7.1
通讯作者：
Willett, Walter C.
中科院分区：
文献类型：
--
作者：
Chavarro, Jorge E.;Rich-Edwards, Janet W.;Willett, Walter C.
背景：药物激活过氧化物酶体增殖物激活受体γ (ppar - γ)可改善多囊卵巢综合征女性的排卵功能，而特定的膳食脂肪酸可影响ppar - γ的活性。目的：本研究的目的是评估总脂肪、胆固醇和主要脂肪酸类型的摄入量是否影响排卵期不孕的风险。设计：我们进行了一项前瞻性队列研究，纳入了18555名在1991年至1999年期间尝试怀孕或怀孕的已婚、无不孕史的绝经前妇女。在随访期间，通过食物频率问卷对饮食进行了两次评估。结果：随访期间共报告排卵性不孕症438例。在logistic回归分析中，总脂肪、胆固醇和大多数类型脂肪酸的摄入量与排卵期不孕无关。与碳水化合物相比，从反式不饱和脂肪中摄取的能量每增加2%，在对已知和可疑的风险因素进行调整后，排卵性不孕症的风险增加73%[相对风险(RR) = 1.73；95% Cl: 1.09, 2.73]。从反式脂肪中获取2%的能量而不是从n-6多不饱和脂肪中获取能量，与排卵性不孕的风险增加相似（RR = 1.79; 95% Cl: 1.11, 2.89）。此外，从反式脂肪中获取2%的能量比从单不饱和脂肪中获取2%的能量与排卵性不孕的风险增加一倍以上相关（RR = 2.31; 95% Cl: 1.09, 4.87）。结论：用反式不饱和脂肪代替非氢化植物油中常见的碳水化合物或不饱和脂肪，可能会增加排卵期不孕的风险。
Background: Pharmacologic activation of the peroxisome proliferator-activated receptor gamma (PPAR-gamma) improves ovulatory function in women with polycystic ovary syndrome, and specific dietary fatty acids can affect PPAR-gamma activity.Objective: The objective of the study was to assess whether the intakes of total fat, cholesterol, and major types of fatty acids affect the risk of ovulatory infertility.Design: We conducted a prospective cohort study of 18 555 married, premenopausal women without a history of infertility who attempted a pregnancy or became pregnant between 1991 and 1999. Diet was assessed twice during follow-up by using a food-frequency questionnaire.Results: During follow-up, 438 incidents of ovulatory infertility were reported. In logistic regression analyses, intakes of total fat, cholesterol, and most types of fatty acids were not related to ovulatory infertility. Each 2% increase in the intake of energy from trans unsaturated fats, as opposed to that from carbohydrates, was associated with a 73% greater risk of ovulatory infertility after adjustment for known and suspected risk factors for this condition [relative risk (RR) = 1.73; 95% Cl: 1.09, 2.73]. Obtaining 2% of energy intake from trans fats rather than from n-6 polyunsaturated fats was associated with a similar increase in the risk of ovulatory infertility (RR = 1.79; 95% Cl: 1.11, 2.89). In addition, obtaining 2% of energy from trans fats rather than from monounsaturated fats was associated with a more than doubled risk of ovulatory infertility (RR = 2.31; 95% Cl: 1.09, 4.87).Conclusion: trans Unsaturated fats may increase the risk of ovulatory infertility when consumed instead of carbohydrates or unsaturated fats commonly found in nonhydrogenated vegetable oils.