Immune system and COVID-19 by sex differences and age.
Immune system and COVID-19 by sex differences and age.
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DOI：
10.1177/17455065211022262
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发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
Giordano M
中科院分区：
文献类型：
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作者：
Ciarambino T;Para O;Giordano M
据报道，在COVID-19疾病中，严重程度和死亡率存在性别差异。本综述的目的是强调对COVID-19免疫反应的性别差异。使用PubMed识别纳入的研究，直至2020年10月30日。检索包括以下关键词：SARS-CoV-2、COVID-19、性别、年龄、性别和免疫系统。文献描述，与男性相比，女性具有更大的炎症、抗病毒和体液免疫应答。在女性中，雌激素是缓解SARS-COV-2疾病的潜在盟友。在男性中，睾酮降低疫苗接种反应并抑制细胞因子反应。在老年患者中，特别是在女性老年患者中，已报告免疫系统的进行性功能下降。在包括SARS-CoV-2在内的感染疾病方面，报告了性别差异。这些数据应得到其他流行病学研究的证实。
In COVID-19 disease, are reported gender differences in relation to severity and death. The aim of this review is to highlight gender differences in the immune response to COVID-19. The included studies were identified using PubMed, until 30 October 2020. The search included the following keywords: SARS-CoV-2, COVID-19, gender, age, sex, and immune system. Literature described that females compared to males have greater inflammatory, antiviral, and humoral immune responses. In female, estrogen is a potential ally to alleviate SARS-COV-2 disease. In male, testosterone reduces vaccination response and depresses the cytokine response. In the older patients, and in particular, in female older patients, it has been reported a progressive functional decline in the immune systems. Differences by gender were reported in infection diseases, including SARS-CoV-2. These data should be confirmed by the other epidemiological studies.