Dietary intake of trans fatty acids and systemic inflammation in women
Dietary intake of trans fatty acids and systemic inflammation in women
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DOI：
10.1093/ajcn/79.4.606
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发表时间：
2004-04-01
影响因子：
7.1
通讯作者：
Rimm, EB
中科院分区：
文献类型：
--
作者：
Mozaffarian, D;Pischon, T;Rimm, EB
背景：反式脂肪酸（TFA）摄入量可预测冠心病和糖尿病的风险。全身性炎症可能参与了这些疾病的发病机制;然而，TFA摄入量和全身性炎症之间的关系还没有很好地建立起来。目的：我们研究了TFA摄入量和炎症标志物之间的关系。设计：在护士健康研究I和II中的823名健康女性中，可溶性肿瘤坏死因子a受体1和2的浓度检测血清可溶性肿瘤坏死因子受体（sTNF-R1，sTNF-R2）、白细胞介素6（IL-6）和C反应蛋白（CRP）水平。结果：在年龄校正分析中，TFA摄入量与sTNF-R1和sTNF-R2呈正相关（各趋势P < 0.001）：sTNF-R1和sTNF-R2浓度为10%摄入量最高的五分位数中，比摄入量最低的五分位数分别高出108 pg/mL（+ 108 pg/mL; 95% CI：50，167 pg/mL）和12%（+258 pg/mL; 138，377 pg/mL）。通过调整体重指数、吸烟、体力活动、阿司匹林和非甾体类抗炎药使用、饮酒、饱和脂肪、蛋白质、n-6和n-3脂肪酸、纤维和总能量的摄入量，这些相关性没有明显改变。调整血清脂质浓度部分衰减这些协会，这表明他们可能部分介导的影响TFAs对血脂。总的来说，TFA摄入量与IL-6或CRP浓度无关，但在体重指数较高的女性中，TFA摄入量与IL-6和CRP呈正相关（相互作用P = 0.03）。需要进一步研究TFA对炎症的影响以及对冠心病、糖尿病和其他疾病的影响。
Background: trans Fatty acid (TFA) intake predicts risks of coronary artery disease and diabetes. Systemic inflammation may be involved in the pathogenesis of such conditions; however, relations between TFA intake and systemic inflammation are not well established.Objective: We investigated the relations between TFA intake and inflammatory markers.Design: In 823 generally healthy women in the Nurses' Health Study I and II, concentrations of soluble tumor necrosis factor a receptors 1 and 2 (sTNF-R1, sTNF-R2), interleukin 6 (IL-6), and C-reactive protein (CRP) were measured. Usual dietary intakes assessed from 2 semiquantitative food-frequency questionnaires were averaged for each subject.Results: In age-adjusted analyses, TFA intake was positively associated with sTNF-R1 and sTNF-R2 (P for trend < 0.001 for each): sTNF-R1 and sTNF-R2 concentrations were 10% (+ 108 pg/mL; 95% CI: 50,167 pg/mL) and 12% (+258 pg/mL; 138,377 pg/mL) higher, respectively, in the highest intake quintile than m the lowest. These associations were not appreciably altered by adjustment for body mass index, smoking, physical activity, aspirin and nonsteroidal antiinflammatory drug use, alcohol consumption, and intakes of saturated fat, protein, n-6 and n-3 fatty acids, fiber, and total energy. Adjustment for serum lipid concentrations partly attenuated these associations, which suggests that they may be partly mediated by effects of TFAs on serum lipids. TFA intake was not associated with IL-6 or CRP concentrations overall but was positively associated with IL-6 and CRP in women with higher body mass index (P for interaction = 0.03 for each).Conclusions: TFA intake is positively associated with markers of systemic inflammation in women. Further investigation of the influences of TFAs on inflammation and of implications for coronary disease, diabetes, and other conditions is warranted.