HIGH SUSCEPTIBILITY OF STRAIN A MICE TO ENDOTOXIN AND ENDOTOXIN-RED BLOOD CELL MIXTURES
HIGH SUSCEPTIBILITY OF STRAIN A MICE TO ENDOTOXIN AND ENDOTOXIN-RED BLOOD CELL MIXTURES
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DOI：
10.1128/jb.90.3.696-703.1965
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发表时间：
1965-01-01
影响因子：
3.2
通讯作者：
WEISS, DW
中科院分区：
文献类型：
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作者：
HEPPNER, G;WEISS, DW
A系小鼠比其他几种品系的小鼠更容易受到内毒素脂多糖（LPS）的致死作用。亚致死量的LPS和绵羊红细胞的复合物对A系小鼠具有协同毒性。绵羊红细胞和热杀鲑鱼，在任何顺序和长达24小时的间隔，单独管理，也证明是协同致死的菌株A小鼠，但不是RIII动物进行比较研究。绵羊红细胞裂解物具有完整细胞与杀鲑精形成致死组合的能力。菌株A红细胞杀死的鲑鱼复合物也是致命的菌株A小鼠，但那么复合物与绵羊红细胞。A × RIIIF1杂交动物显示出与抗性RIIIF1杂交动物相同的抗性特征，其显示出与抗性RIII亲本菌株相同的抗性特征。对这些发现的可能解释提出了建议，并讨论了它们与内毒素致死作用的免疫学模式的相关性。
Strain A mice were shown to be considerably more susceptible to lethal effects of endotoxin lipolysaccharide (LPS) than mice of several other strains. Complexes of sublethal quantities of LPS and sheep red blood cells were synergistically toxic for strain A mice. Separate administration of sheep red blood cells and heat-killed salmonellae, in either order and as long as 24 hr apart, also proved to be synergistically lethal for strain A mice, but not for RIII animals studied comparatively. Sheep red blood cell lysates possessed the ability of the intact cells in forming lethal combinations for strain A mice with killed salmonellae. Strain A red blood cell-killed salmonellae complexes were also lethal for strain A mice, but less so then complexes made with sheep red blood cells. A x RIIIF1 hybrid animals showed the same resistance characteristics as the resistant RIIIF1 hybrid animals showed the same resistance characteristics as the resistant RIII parental strain. Possible explanations for these findings are suggested, and their relevance to an immunological mode of action of endotoxin lethality is discussed.