Negative Association between Metabolic Syndrome and Bone Mineral Density in Koreans, Especially in Men
Negative Association between Metabolic Syndrome and Bone Mineral Density in Koreans, Especially in Men
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DOI：
10.1007/s00223-010-9347-2
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发表时间：
2010-05-01
影响因子：
4.2
通讯作者：
Kim, Ghi Su
中科院分区：
文献类型：
--
作者：
Kim, Ha Young;Choe, Jae Won;Kim, Ghi Su
心血管疾病和骨质疏松症被认为有共同的危险因素，代谢综合征（MS）是心血管疾病的主要危险因素。本研究旨在探讨特定MS组分与骨密度（BMD）之间的关系。使用双能X线吸收法测量40岁或以上韩国男性（n = 1，780）和绝经后女性（n = 1，108）的股骨颈BMD。我们根据国际糖尿病联合会（IDF）和美国心脏协会/国家心肺血液研究所（AHA/NHLBI）的两个标准确定了MS受试者。通过生物阻抗分析测量体脂和瘦体重。根据AHA/NHLBI定义和IDF定义，MS的患病率在男性中分别为19.8%和7.7%，在绝经后女性中分别为20.8%和11.6%。多变量校正后，无论诊断标准如何，MS受试者的股骨颈BMD均显著降低。随着MS组分数量的增加，BMD降低（两性趋势P < 0.001）。在MS组分中，腰围是这种负相关的最重要因素。当多元线性回归模型应用于每个5公斤的体重分层，以测试线性趋势，腰围和脂肪量与BMD呈负相关，瘦体重与BMD在男性，但不是在女性。在韩国男性和绝经后女性中，MS与较低的BMD相关，这表明内脏脂肪可能导致骨丢失，尤其是在男性中。
Cardiovascular disease and osteoporosis are thought to share common risk factors, and metabolic syndrome (MS) is composed of major risk factors for cardiovascular disease. This study was performed to investigate the relationships between specific MS components and bone mineral density (BMD). BMD was measured at the femoral neck of Korean men aged 40 years or more (n = 1,780) and postmenopausal women (n = 1,108) using dual-energy X-ray absorptiometry. We identified subjects with MS as defined by two criteria, International Diabetes Federation (IDF) and American Heart Association/National Heart, Lung, and Blood Institute (AHA/NHLBI). Body fat and lean mass were measured via bioimpedance analysis. The prevalence of MS was 19.8% and 7.7% in men and 20.8% and 11.6% in postmenopausal women according to the AHA/NHLBI definition and the IDF definition, respectively. After multivariate adjustment, femoral neck BMD was significantly lower in subjects with MS regardless of diagnostic criteria. BMD decreased as the number of MS components increased (P < 0.001 for trends in both sexes). Among MS components, waist circumference was the most important factor in this negative association. When multiple linear regression models were applied to each 5-kg weight stratum to test for a linear trend, waist circumference and fat mass were negatively associated with BMD and lean mass was positively associated with BMD in men but not in women. MS was associated with a lower BMD in Korean men and postmenopausal women, suggesting that visceral fat may lead to bone loss, especially in men.