Calcium wave propagation during cell extrusion
Calcium wave propagation during cell extrusion
复制标题
细胞挤压过程中钙波的传播
DOI：
10.1016/j.ceb.2022.102083
复制
发表时间：
2022
影响因子：
7.5
通讯作者：
Matsui Takaaki
中科院分区：
文献类型：
--
作者：
Okochi Yasushi;Matsui Takaaki;Naoki Honda;Matsui Takaaki
通过转化/凋亡细胞（挤出细胞）和最近的相邻细胞之间的细胞间通讯，将致癌转化或凋亡细胞从上皮片中去除。细胞挤压是由肌动球蛋白收缩和最近相邻细胞的板状足爬行驱动的。最近的研究发现，远端细胞通讯也在细胞挤出中发挥作用。具体来说，距离挤出细胞 3-16 个细胞的远端细胞通过钙波协调，共同向挤出细胞迁移以启动细胞挤出。在这里，我描述了钙波是如何产生的，以及如何促进哺乳动物和斑马鱼细胞的挤压。
Oncogenically transformed or apoptotic cells are removed from epithelial sheets by cell–cell communication between the transformed/apoptotic cells (extruding cells) and the nearest neighboring cells. Cell extrusion is driven by actomyosin contraction and lamellipodial crawling of the nearest neighboring cells. Recent studies have found that distal cell communication also plays a role in cell extrusion. Specifically, distal cells located 3–16 cells away from the extruding cell are coordinated by calcium waves and collectively migrate toward the extruding cell to initiate cell extrusion. Here, I describe how calcium waves are generated and contribute to the extrusion of cells in mammals and zebrafish.