Predicting cognitive decline in healthy older adults
Predicting cognitive decline in healthy older adults
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DOI：
10.1176/appi.ajgp.13.8.735
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发表时间：
2005-08-01
影响因子：
7.2
通讯作者：
Sahakian, BJ
中科院分区：
文献类型：
--
作者：
De Jager, C;Blackwell, AD;Sahakian, BJ
目的：作者对一组社区居住的健康老年志愿者中哪些人会出现认知能力下降进行了神经心理学测定。方法：155名自称记忆力和思维良好的志愿者参加了一项为期4年的前瞻性研究。作者监测了认知功能和轻度认知障碍(MCI)/阿尔茨海默病（AD）的发病率。结果：基线评估显示一个亚组参与者在联想学习和命名方面存在缺陷；这些人随后的认知能力下降更为急剧，他们也表现出较高的MCI/AD相对风险。结论：认知测量可用于社区和临床痴呆筛查，并可用于识别抗痴呆治疗试验的富集样本。
Objective: Authors performed a neuropsychological determination of which individuals in a group of community-dwelling, healthy elderly volunteers would develop cognitive decline. Methods: A group of 155 volunteers reporting good memory and thinking participated in a prospective study over 4 years. Authors monitored cognitive functioning and incidence of Mild Cognitive Impairment (MCI)/Alzheimer disease (AD). Results: Baseline assessment revealed a subgroup of participants with deficits in associative learning and naming; subsequent cognitive decline was more precipitous in these individuals, who also showed higher relative risk of MCI/AD. Conclusion: Cognitive measures may be useful in community and clinical dementia screening and applicable for identifying enriched samples for trials of anti-dementia treatments.