T-cell exhaustion in the tumor microenvironment.
T-cell exhaustion in the tumor microenvironment.
复制标题
DOI：
10.1038/cddis.2015.162
复制
发表时间：
2015-06-18
影响因子：
9
通讯作者：
Zhu B
中科院分区：
文献类型：
--
作者：
Jiang Y;Li Y;Zhu B
T细胞耗竭最初是在小鼠慢性感染期间发现的，随后在患有癌症的人类中观察到。肿瘤微环境中耗尽的T细胞表现出过表达的抑制性受体，降低的效应细胞因子产生和细胞溶解活性，导致癌症消除失败。恢复耗尽的T细胞是一种鼓舞人心的癌症治疗策略，已经取得了可喜的成果，成为癌症免疫治疗的重大突破。本文综述了近年来对肿瘤衰竭T细胞及其调控机制的最新认识，并对目前针对衰竭T细胞的临床治疗措施进行了讨论。
T-cell exhaustion was originally identified during chronic infection in mice, and was subsequently observed in humans with cancer. The exhausted T cells in the tumor microenvironment show overexpressed inhibitory receptors, decreased effector cytokine production and cytolytic activity, leading to the failure of cancer elimination. Restoring exhausted T cells represents an inspiring strategy for cancer treatment, which has yielded promising results and become a significant breakthrough in the cancer immunotherapy. In this review, we overview the updated understanding on the exhausted T cells in cancer and their potential regulatory mechanisms and discuss current therapeutic interventions targeting exhausted T cells in clinical trials.