RESPONSE PROPERTIES OF RAT OLFACTORY-BULB NEURONS
RESPONSE PROPERTIES OF RAT OLFACTORY-BULB NEURONS
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DOI：
10.1113/jphysiol.1982.sp014197
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发表时间：
1982-01-01
影响因子：
5.5
通讯作者：
MAIR, RG
中科院分区：
文献类型：
--
作者：
MAIR, RG
用空气稀释嗅觉仪记录刺激诱发的单位活动，研究大鼠嗅球神经元的反应特性。神经反应被量化为刺激周围时间直方图，方法是对同一刺激的8次呈现所引起的反应进行平均。通过连接到后鼻孔的真空源产生的受控人工嗅觉来刺激动物。诱发活动分为反应时反应和反应后反应。根据气味刺激引起的活动的时间模式，我们区分了三种类型的ON反应。当神经元受到不同气味的驱动时，表现出相同类型的反应。对于给定的神经元，诱发反应的大小取决于用作刺激物质的气味。特定气味的刺激效果在不同的神经元之间有所不同。后反应分为两类：相性反应(刺激抵消后0.5~3 S)和紧张性反应(刺激抵消后3 S~2min)。后反应与产生每种类型的ON反应的神经元的子集有关，而与不产生明显ON反应的单位有关。后反应在给定神经元中的出现可能不依赖于诱发的ON反应的性质。ON反应的强度相关变化由3个指标表征：刺激事件中诱发的动作电位数、动作电位爆发潜伏期和动作电位爆发时的活动率。诱发动作电位的数目与刺激浓度不是单调相关的。诱发活动的模式与刺激浓度之间存在明显的关系。显然，兴奋和抑制的时间取决于刺激的浓度，诱发的动作电位的数量取决于用作刺激物质的气味和它传递的浓度。
Response properties of rat olfactory bulb neurons were studied by recording single-unit activity evoked by stimuli delivered by an air-dilution olfactometer. Neural responses were quantified as peristimulus time histograms by averaging the responses evoked by 8 presentations of the same stimulus. Animals were stimulated by means of controlled artificial sniffs produced by a vacuum source connected to the choana. Evoked activity was divided into on- and after-responses. Three types of on-responses were distinguished on the basis of temporal patterns of activity evoked by odorous stimuli. Neurons exhibited the same type of response when driven by different odorants. For a given neuron, the size of an evoked response depended on the odorant used as a stimulus substance. The stimulating effectiveness of particular odorants varied between different neurons. After-responses were divided into 2 classes: phasic (0.5-3 s after stimulus offset) and tonic (3 s-2 min after stimulus offset). After-responses were associated with a subset of neurons making each type of on-response and with units producing no clear on-response. The occurrence of an after-response in a given neuron may not be dependent on the nature of the evoked on-response. Intensity-related changes of on-responses were characterized by 3 measures: number of action potentials evoked during the stimulus event, latency of action-potential bursts, and rate of activity during the action-potential bursts. The number of evoked action potentials was not monotonically related to stimulus concentration. There was a clear relationship between the pattern of evoked activity and stimulus concentration. Apparently, the timing of excitation and inhibition is dependent on the concentration of the stimulus and the number of evoked action potentials depends on the odorant used as a stimulus substance and the concentration at which it is delivered.