Discriminative fear conditioning to context expressed by multiple measures of fear in the rat
Discriminative fear conditioning to context expressed by multiple measures of fear in the rat
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DOI：
10.1016/s0166-4328(98)00056-4
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发表时间：
1999-05-01
影响因子：
2.7
通讯作者：
McDonald, RJ
中科院分区：
文献类型：
--
作者：
Antoniadis, EA;McDonald, RJ
人们对恐惧情境调节的神经基础重新产生了兴趣。这些当前的方法伴随着一些局限性，包括使用短测试窗口，非歧视性范式和单一的恐惧反应评估。为了规避这些限制，本研究使用了一种评估恐惧多重反应措施的判别上下文程序。条件训练包括三次训练，每次训练为期2天。第一天，这些动物被置于成对的环境中，接受三次足部电击。另一天，他们被放置在没有任何厌恶事件的单独房间里。每次训练结束后对动物进行测试，记录恐惧的反应指标包括：偏好、冻结、心率、超声波发声、排便、体温、排尿和运动。结果表明，恐惧刺激引起的行为和生理变化与厌恶事件发生的环境有关。总的来说，这些发现还表明，在这种范式中，对恐惧的测量有不同的学习参数。(C) 1999 Elsevier Science B.V.版权所有
There has been a renewed interest in the neural basis of fear conditioning to context. These current approaches are accompanied by some limitations including the use of short testing windows, non-discriminative paradigms, and unitary fear response assessment. In an attempt to circumvent these limitations, a discriminative context procedure assessing multiple response measures of fear was used in the present study. Conditioning consisted of three training sessions and each session consisted of 2 days. On day one, the animals were placed in the paired context and received three foot shocks. On the other day, they were placed in the unpaired chamber in the absence of any aversive event. Animals were tested after each training session and the response measures of fear recorded included: preference, freezing, heart rate, ultrasonic vocalizations, defecation, body temperature, urination and locomotion. The results suggest that behavioral, as well as physiological changes evoked by fearful stimuli become associated with the context in which the aversive event occurred. In general these findings also suggest that there are different learning parameters for the measures of fear examined in this paradigm. (C) 1999 Elsevier Science B.V. All rights reserved.