Karyotypic stasis and swarming influenced the evolution of viral tolerance in a species-rich bat radiation
Karyotypic stasis and swarming influenced the evolution of viral tolerance in a species-rich bat radiation
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DOI：
10.1016/j.xgen.2023.100482
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发表时间：
2024-02-14
期刊：
影响因子：
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通讯作者：
Murphy，William J.
中科院分区：
文献类型：
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作者：
Foley，Nicole M.;Harris，Andrew J.;Murphy，William J.
COVID-19和严重急性呼吸道综合征（SARS）的出现使人们优先了解蝙蝠的病毒耐受性。鼠耳蝠物种丰富，已经进化出病毒耐受性。它们还表现出群集，这是一种神秘的行为，大型的多物种聚集在一起交配，这被假设为促进种间杂交。为了解决基因组结构的共同进化及其不寻常的抗病毒耐受性，我们对60个旧世界鼠耳蝠基因组进行了基因组分析。我们展示了一个广泛的渐渗杂交的历史，除了大染色体的近着丝粒区域外，它已经取代了17%-93%的基因组的物种同源性。在病毒攻击实验期间，渗入道富集在含有过表达的关键抗病毒途径基因的微染色体区域上。总之，这些结果表明，unusualMyotiskaryotype可能已经进化到选择性地定位免疫相关基因在高重组基因组区域倾向于渐渗的不同等位基因，包括多样性的白细胞介素基因座负责释放促炎细胞因子。
The emergence of COVID-19 and severe acute respiratory syndrome (SARS) has prioritized understanding bats' viral tolerance.Myotisbats are exceptionally species rich and have evolved viral tolerance. They also exhibit swarming, a cryptic behavior where large, multi-species assemblages gather for mating, which has been hypothesized to promote interspecific hybridization. To resolve the coevolution of genome architecture and their unusual antiviral tolerance, we undertook a phylogenomic analysis of 60 Old WorldMyotisgenomes. We demonstrate an extensive history of introgressive hybridization that has replaced the species phylogeny across 17%−93% of the genome except for pericentromeric regions of macrochromosomes. Introgression tracts were enriched on microchromosome regions containing key antiviral pathway genes overexpressed during viral challenge experiments. Together, these results suggest that the unusualMyotiskaryotype may have evolved to selectively position immune-related genes in high recombining genomic regions prone to introgression of divergent alleles, including a diversity of interleukin loci responsible for the release of pro-inflammatory cytokines.