Estrogen action in anterior and ventromedial hypothalamus and the modulation of heterosexual behavior in female golden hamsters.
Estrogen action in anterior and ventromedial hypothalamus and the modulation of heterosexual behavior in female golden hamsters.
复制标题
雌激素在下丘脑前部和腹内侧的作用以及雌性金仓鼠异性性行为的调节。
DOI：
10.1016/0031-9384(85)90111-8
复制
发表时间：
1985
影响因子：
2.9
通讯作者：
Lisk,RD
中科院分区：
文献类型：
--
作者：
Takahashi,LK;Lisk,RD
在雌性仓鼠的下丘脑植入雌激素或胆固醇后的三天内，检查了异性恋模式的激动，标记和性行为的变化。动物习惯于大的舞台，允许展示各种各样的行为。雌激素植入物位于腹内侧（VMH），但不是前（AH）部分的下丘脑有效地促进阴道标记的发生，超过两天的雌激素引发期。在这两天的时间里，对抗行为模式的表现显着下降。系统管理的孕酮引起的性感受性在75%的女性VMH组，在AH组中只有25%。下丘脑植入胆固醇的女性在注射孕酮后仍然不接受。结果提供了重要的信息雌激素的作用部位在下丘脑在介导异性之间的相互作用。
Changes in heterosexual patterns of agonistic, marking, and sexual behavior were examined in female hamsters over a three day period following implantation of either estrogen or cholesterol in the hypothalamus. Animals were habituated to large arenas that permit the display of a wide range of behavior. Estrogen implants located in the ventromedial (VMH) but not the anterior (AH) portion of the hypothalamus were effective in facilitating the occurrence of vaginal marking, over a two day estrogen priming period. During this two day period, the exhibition of agonistic behavioral patterns declined significantly. Systemic administration of progesterone elicited sexual receptivity in 75% of the females in the VMH group, in contrast to only 25% in the AH group. Females with hypothalamic implants of cholesterol remained unreceptive following progesterone injections. The results provide important information on the estrogen sites of action at the hypothalamus in mediating heterosexual interactions.