Relationship of Sleep Duration With All-Cause Mortality and Cardiovascular Events: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies.
Relationship of Sleep Duration With All-Cause Mortality and Cardiovascular Events: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies.
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睡眠持续时间与全因死亡率和心血管事件的关系：前瞻性队列研究的系统回顾和剂量反应荟萃分析
DOI：
10.1161/jaha.117.005947
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发表时间：
2017-09-09
影响因子：
5.4
通讯作者：
Liu L
中科院分区：
文献类型：
--
作者：
Yin J;Jin X;Shan Z;Li S;Huang H;Li P;Peng X;Peng Z;Yu K;Bao W;Yang W;Chen X;Liu L
极端睡眠时间对死亡风险和心血管结局的影响仍存在争议。我们旨在量化睡眠时间与全因死亡率、总心血管疾病、冠心病和中风风险的剂量反应关系。PubMed和Embase系统性检索了2016年12月1日之前发表的前瞻性队列研究，这些研究检查了睡眠时间与一般健康人群中4种结局中至少1种结局之间的相关性。睡眠持续时间与所有结局风险之间存在U型相关性，每天睡眠时间超过17小时的风险最低，性别差异很小。对于全因死亡率，当每天睡眠时间<7小时时，每减少1小时，合并相对风险（RR）为1.06（95%CI，1.04-1.07）;当每天睡眠时间>7小时时，合并相对风险（RR）为1.13（95%CI，1.11-1.15）每1小时增量。对于总心血管疾病，每减少1小时的汇总RR为1.06（95% CI，1.03-1.08），每增加1小时的睡眠时间为1.12（95% CI，1.08-1.16）。对于冠心病，睡眠时间每减少1小时的合并RR为1.07（95% CI，1.03-1.12），睡眠时间每增加1小时的合并RR为1.05（95% CI，1.00-1.10）。对于卒中，睡眠时间每减少1小时，合并RR为1.05（95% CI，1.01-1.09），每增加1小时，合并RR为1.18（95% CI，1.14-1.21）。我们的研究结果表明，短时间和长时间的睡眠都与全因死亡率和心血管事件的风险增加有关。
Effects of extreme sleep duration on risk of mortality and cardiovascular outcomes remain controversial. We aimed to quantify the dose‐response relationships of sleep duration with risk of all‐cause mortality, total cardiovascular disease, coronary heart disease, and stroke. PubMed and Embase were systematically searched for prospective cohort studies published before December 1, 2016, that examined the associations between sleep duration and at least 1 of the 4 outcomes in generally healthy populations. U‐shaped associations were indicated between sleep duration and risk of all outcomes, with the lowest risk observed for ≈7‐hour sleep duration per day, which was varied little by sex. For all‐cause mortality, when sleep duration was <7 hours per day, the pooled relative risk (RR) was 1.06 (95% CI, 1.04–1.07) per 1‐hour reduction; when sleep duration was >7 hours per day, the pooled RR was 1.13 (95% CI, 1.11–1.15) per 1‐hour increment. For total cardiovascular disease, the pooled RR was 1.06 (95% CI, 1.03–1.08) per 1‐hour reduction and 1.12 (95% CI, 1.08–1.16) per 1‐hour increment of sleep duration. For coronary heart disease, the pooled RR was 1.07 (95% CI, 1.03–1.12) per 1‐hour reduction and 1.05 (95% CI, 1.00–1.10) per 1‐hour increment of sleep duration. For stroke, the pooled RR was 1.05 (95% CI, 1.01–1.09) per 1‐hour reduction and 1.18 (95% CI, 1.14–1.21) per 1‐hour increment of sleep duration. Our findings indicate that both short and long sleep duration is associated with an increased risk of all‐cause mortality and cardiovascular events.