Striatal tachykinin and enkephalin mRNAs are normalized by serotonin2 and NMDA manipulation following dopamine depletion.
Striatal tachykinin and enkephalin mRNAs are normalized by serotonin2 and NMDA manipulation following dopamine depletion.
复制标题
多巴胺耗竭后，纹状体速激肽和脑啡肽 mRNA 通过 5-羟色胺 2 和 NMDA 操作而正常化。
DOI：
10.1097/00001756-200201210-00006
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发表时间：
2002
期刊：
影响因子：
1.7
通讯作者：
Walker,PaulD
中科院分区：
文献类型：
--
作者：
Campbell,BrianM;Walker,PaulD
We have examined the effects of serotonin 2 (5-HT 2) stimulation and NMDA antagonism on preprotachykinin (PPT) and preproenkephalin (PPE) gene regulation in the dopamine (DA) depleted striatum. Following DA lesions, PPT mRNA expression was reduced (dorsomedial (DM) 44±9%, dorsolateral (DL) 40±4%), whereas PPE message levels were elevated (DM 207±28%, DL 198±25%). Within this state of dysregulated gene activity, DOI (5-HT 2 agonist) increased PPT message levels (174±5%, DM; 153+ 13%, DL) without affecting PPE gene expression. In addition, MK-801 (NMDA antagonist) decreased PPE message levels (DM 59±10%, DL 52±7%) without significantly altering PPT mRNA expression. Combined application of DOI and MK-801 resulted in normalization of both PPT and PPE message. Statistical analysis revealed no drug interactions in this paradigm suggesting independent mechanisms for 5-HT 2 and NMDA receptors in controlling neuropeptide production following DA depletion.
