Depressive symptoms are not associated with forearm bone accrual during adolescence
Depressive symptoms are not associated with forearm bone accrual during adolescence
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DOI：
10.1007/s11657-014-0173-4
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发表时间：
2014-12-01
影响因子：
3
通讯作者：
Barros, Henrique
中科院分区：
文献类型：
--
作者：
Lourenco, Sara;Lucas, Raquel;Barros, Henrique
虽然抑郁症已与最坏的骨物理性能在成年期，这项研究表明，抑郁症状并没有显着相关的骨矿物质密度测量在前臂在adolescence.Purpose抑郁症的条件已与减少骨矿物质密度（BMD）在成年期。虽然有可能假设抑郁症状在青春期对骨矿物质积累有类似的影响，但这种关联的研究很少。因此，我们的目的是研究抑郁症状和前臂骨密度之间的关系在adolescent.Methods这项研究是基于流行病学健康调查的青少年队列，抽样青少年出生于1990年，就读于公立和私立学校的波尔图在2003/2004学年。在基线（n= 2，160）和17岁（n= 1，716）时，使用Beck抑郁量表-II（BDI-II）评估抑郁症状。使用双能X射线吸收法测量非优势前臂的BMD（克/平方厘米）。性别特异性粗和校正线性回归系数（β）和相应的95%置信区间结果在青春期早期和晚期，男性和女性的抑郁症状与前臂骨密度无显著相关性（β（女孩13）=0.09，95% CI=-0.43至0.61; β（女孩17）=0.10，95% CI=-0.43至0.64; β（男孩13）=-0.10，95% CI=-0.96至0.76; β（男孩17）=0.49，95% CI=-0.96至1.93）。同样，在青春期，男孩和女孩的抑郁症状与前臂骨密度的年变化之间也没有显著的联系（beta（女孩）_（BDI-II）_（13-17）_（剩余）_（最低）=-0.85，95% CI=-4.62至2.92 vs. beta（女孩）_（BDI-II）_（13-17）_最高残留量=-1.87，95%CI =-5.06 ~1.31; beta（男孩）_（BDI-II）_（13-17）_（剩余）_（最低）=0.48，95% CI=-5.30至6.26 vs. beta（男孩）_（BDI-II）_（13-17）_（remained）_（highest）=1.36，95%CI =-3.25 ~5.97）。结论抑郁症状在一般青少年人群中存在，与青春期前臂骨密度的变化无关。为了检测抑郁症对骨骼生长的全身影响，需要对不同骨骼部位的测量进行进一步研究。
A Summary Although depression has been associated to worst bone physical properties in adulthood, this study showed that depressive symptoms were not significantly associated to bone mineral density measured at the forearm during adolescence.Purpose Depressive conditions have been related to the reduction of bone mineral density (BMD) in adulthood. Though it is possible to hypothesize that depressive symptoms present similar effects in bone mineral accrual during adolescence, such association is poorly researched. Therefore, we aimed to study the relation between depressive symptoms and forearm BMD during adolescence.Methods The study is based on the Epidemiological Health Investigation of Teenagers cohort that sampled adolescents born in 1990 and enrolled in public and private schools of Porto during the 2003/2004 academic year. At baseline (n=2,160) and at 17 years of age (n=1,716), depressive symptoms were evaluated using the Beck Depression Inventory-II (BDI-II). BMD (grams per square centimetre) was measured at the non-dominant forearm using dual-energy X-ray absorptiometry. Sex-specific crude and adjusted linear regression coefficients (beta) and the corresponding 95 % confidence intervals (95 % CIs) were calculated to estimate the cross-sectional and prospective associations between depressive symptoms and forearm BMD.Results In both sexes, in early and late adolescence, depressive symptoms presented no statistically significant association with forearm BMD (beta(Girls13)=0.09, 95 % CI=-0.43 to 0.61; beta(Girls17)=0.10, 95 % CI=-0.43 to 0.64; beta(Boys13)=-0.10, 95 % CI=-0.96 to 0.76; beta(Boys17)=0.49, 95 % CI=-0.96 to 1.93). Similarly, there were no significant associations between depressive symptoms and the annual forearm BMD change during adolescence in girls and boys (beta(Girls)_(BDI-II)_(13-17)_(remained)_(lowest)=-0.85, 95 % CI=-4.62 to 2.92 vs. beta(Girls)_(BDI-II)_(13-17)_(remained)_(highest)=-1.87, 95 % CI=-5.06 to 1.31; beta(Boys)_(BDI-II)_(13-17)_(remained)_(lowest)=0.48, 95 % CI=-5.30 to 6.26 vs. beta(Boys)_(BDI-II)_(13-17)_(remained)_(highest)=1.36, 95 % CI=-3.25 to 5.97).Conclusions Depressive symptoms, with the range of severity observed in the general adolescent population, were not associated with changes in forearm bone mineral density during adolescence. Further research based on measurements of different skeletal sites is needed in order to detect a systemic effect of depression on growing bone.