Tobacco product use and the risks of SARS-CoV-2 infection and COVID-19: current understanding and recommendations for future research.
Tobacco product use and the risks of SARS-CoV-2 infection and COVID-19: current understanding and recommendations for future research.
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DOI：
10.1016/s2213-2600(22)00182-5
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发表时间：
2022-09
影响因子：
76.2
通讯作者：
Bhatnagar, Aruni
中科院分区：
文献类型：
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作者：
Benowitz, Neal L.;Goniewicz, Maciej L.;Halpern-Felsher, Bonnie;Krishnan-Sarin, Suchitra;Ling, Pamela M.;O'Connor, Richard J.;Pentz, Mary Ann;Robertson, Rose Marie;Bhatnagar, Aruni
SARS-CoV-2 感染和 COVID-19 进展的临床表现的异质性凸显了迫切需要确定影响感染易感性和疾病严重程度的个体水平易感因素。烟草制品的使用是一个潜在的易感因素。在本个人观点中，我们概述了有关烟草产品使用与 SARS-CoV-2 感染和 COVID-19 结果的同行评审、已发表研究的结果，其中大多数研究侧重于成人吸烟。有关烟草制品使用对 SARS-CoV-2 感染发病率影响的研究结果并不一致。然而，有证据支持吸烟会增加 COVID-19 不良结果的风险，包括入院、疾病严重程度进展和与 COVID-19 相关的死亡率。我们讨论了烟草使用行为对 SARS-CoV-2 传播和感染的潜在影响，并强调了与吸烟相关的病理生理变化，这些变化可能促进 SARS-CoV-2 感染并增加疾病严重程度。我们考虑尼古丁和其他烟草产品成分可能影响 SARS-CoV-2 感染的免疫和炎症反应的生物学机制。最后，我们确定了当前的知识差距，并建议研究重点，以解决大流行期间和之后 COVID-19 的急性和急性后健康后果。
Heterogeneity in the clinical presentation of SARS-CoV-2 infection and COVID-19 progression underscores the urgent need to identify individual-level susceptibility factors that affect infection vulnerability and disease severity. Tobacco product use is a potential susceptibility factor. In this Personal View, we provide an overview of the findings of peer-reviewed, published studies relating tobacco product use to SARS-CoV-2 infection and COVID-19 outcomes, with most studies focusing on cigarette smoking in adults. Findings pertaining to the effects of tobacco product use on the incidence of SARS-CoV-2 infection are inconsistent. However, evidence supports a role for cigarette smoking in increasing the risk of poor COVID-19 outcomes, including hospital admission, progression in disease severity, and COVID-19-related mortality. We discuss the potential effects of tobacco use behaviour on SARS-CoV-2 transmission and infection, and highlight the pathophysiological changes associated with cigarette smoking that could promote SARS-CoV-2 infection and increased disease severity. We consider the biological mechanisms by which nicotine and other tobacco product constituents might affect immune and inflammatory responses to SARS-CoV-2 infection. Finally, we identify current knowledge gaps and suggest priorities for research to address acute and post-acute health outcomes of COVID-19 during and after the pandemic.
影响因子：
3.7
作者：
Yang Y;Lindblom EN;Salloum RG;Ward KD
通讯作者：
Ward KD
DOI：
10.1007/s11356-020-11038-x
发表时间：
2021-08
期刊：
Environmental science and pollution research international
影响因子：
--
作者：
Kalan ME;Ghobadi H;Taleb ZB;Adham D;Cobb CO;Ward KD;Behaleh R;Fazlzadeh M
通讯作者：
Fazlzadeh M