Mass spectrometric characterization of a high-field asymmetric waveform ion mobility spectrometer
Mass spectrometric characterization of a high-field asymmetric waveform ion mobility spectrometer
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DOI：
10.1063/1.1149255
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发表时间：
1998-12-01
影响因子：
1.6
通讯作者：
Matyjaszczyk, MS
中科院分区：
文献类型：
--
作者：
Purves, RW;Guevremont, R;Matyjaszczyk, MS
离子迁移谱（IMS）已成为一种重要的方法，用于检测许多化合物，因为它的高灵敏度和适应小型化的现场便携式监测;应用包括检测毒品，爆炸物和化学战剂。高场非对称波形离子迁移谱（FAIMS）与IMS的不同之处在于，电场是使用高频周期性非对称波形而不是直流电压施加的。此外，在FAIMS中，化合物通过离子在高电场下相对于低电场的迁移率的差异来分离，而不是通过化合物与化合物在低电场（IMS）下的迁移率差异来分离。我们在这里报告的第一个圆柱形几何FAIMS接口与质谱（FAIMS-MS）和MS识别FAIMS补偿电压（CV）谱中观察到的峰。使用基于静电计的FAIMS（FAIMS-E）和FAIMS-MS，影响离子检测灵敏度的几个变量进行了检查两个（极性反转）不对称波形（模式1和2），每个波形产生一个独特的光谱。分散电压（DV）的增加被发现，以提高FAIMS CV光谱中观察到的灵敏度和分离。这种灵敏度的增加和模式1和2中的意外不同表明，在FAIMS分析仪中发生了大气压离子聚焦。CV光谱中的灵敏度和峰位置受温度、气体流速、操作压力和分析物浓度的影响。(C)1998年美国物理学会。[S0034-6748（98）02412-5]。
Ion mobility spectrometry (IMS) has become an important method for the detection of many compounds because of its high sensitivity and amenability to miniaturization for field-portable monitoring; applications include detection of narcotics, explosives, and chemical warfare agents. High-field asymmetric waveform ion mobility spectrometry (FAIMS) differs from IMS in that the electric fields are applied using a high-frequency periodic asymmetric waveform, rather than a dc voltage. Furthermore, in FAIMS the compounds are separated by the difference in the mobility of ions at high electric field relative to low field, rather than by compound to compound differences in mobility at low electric field (IMS). We report here the first cylindrical-geometry-FAIMS interface with mass spectrometry (FAIMS-MS) and the MS identification of the peaks observed in a FAIMS compensation voltage (CV) spectrum. Using both an electrometer-based-FAIMS (FAIMS-E) and FAIMS-MS, several variables that affect the sensitivity of ion detection were examined for two (polarity reversed) asymmetric waveforms (modes 1 and 2) each of which yields a unique spectrum. An increase in the dispersion voltage (DV) was found to improve the sensitivity and separation observed in the FAIMS CV spectrum. This increase in sensitivity and the unexpected dissimilarity in modes 1 and 2 suggest that atmospheric pressure ion focusing is occurring in the FAIMS analyzer. The sensitivity and peak locations in the CV spectra were affected by temperature, gas flow rates, operating pressure, and analyte concentration. (C) 1998 American Institute of Physics. [S0034-6748(98)02412-5].