Expression of CAVEOLIN 1 in uterine mesenchymal tumors: No relationship between malignancy and CAVEOLIN 1 expression
Expression of CAVEOLIN 1 in uterine mesenchymal tumors: No relationship between malignancy and CAVEOLIN 1 expression
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DOI：
10.1016/j.bbrc.2015.06.046
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发表时间：
2015-08-07
影响因子：
3.1
通讯作者：
Konishi, Ikuo
中科院分区：
文献类型：
--
作者：
Hayashi, Takuma;Ichimura, Tomoyuki;Konishi, Ikuo
虽然在人类子宫中发现的大多数平滑肌肿瘤是良性的，但子宫平滑肌肉瘤(Ut-LMS)是高度恶性的，复发和转移率很高。小窝蛋白I(CAV1)在某些肿瘤的上皮细胞中的水平已被报道在肿瘤进展过程中升高。在此，我们在几个临床机构评估了CAV1的表达与诊断为子宫间充质肿瘤的患者的病理特征的关系。CAV1的表达与人子宫间充质肿瘤的恶性程度之间没有临床联系。CAV1在正常子宫肌层中表达降低，而在子宫间充质肿瘤中表达较强。然而，CAV1的表达并不是区分Ut-LMS与其他类型子宫间充质肿瘤的潜在生物标志物。CAV1在所有类型的子宫间充质肿瘤和子宫肌层中均有明显的血管周围表达。因此，本研究结果提示CAV1可能不是子宫恶性间充质瘤的潜在生物标志物。(C)2015 Elsevier Inc.保留所有权利。
Although most smooth muscle neoplasms detected in the human uterus are benign, uterine leiomyosarcoma (Ut-LMS) is extremely malignant with high rates of recurrence and metastasis. CAVEOLIN I (CAV1) levels in the epithelial cells of some carcinomas have been reported to increase during tumor progression. We herein evaluated the relationship between CAV1 expression and the pathological features of patients diagnosed with uterine mesenchymal tumors at several clinical facilities. No clinical link was observed between CAV1 expression and the malignancy of human uterine mesenchymal tumors. CAV1 expression was decreased in the normal myometrium, whereas it was strongly expressed in uterine mesenchymal tumors. However, the expression of CAV1 was not a potential biomarker to distinguish Ut-LMS from other types of uterine mesenchymal tumors. The perivascular expression of CAV1 was clearly observed in all types of uterine mesenchymal tumors and myometria. Therefore, the results of the present study suggest that CAV1 may not act as a potential biomarker of uterine malignant mesenchymal tumors. (C) 2015 Elsevier Inc. All rights reserved.