Sporadic rippling muscle disease unmasked by simvastatin
Sporadic rippling muscle disease unmasked by simvastatin
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DOI：
10.1002/mus.20575
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发表时间：
2006-10-01
期刊：
影响因子：
3.4
通讯作者：
Tarnopolsky, Mark A.
中科院分区：
文献类型：
--
作者：
Baker, Steven K.;Tarnopolsky, Mark A.
我们报告一位53岁的男性患者在开始辛伐他汀治疗高胆固醇血症2个月后出现了波纹肌病（RMD）。他有僵硬，肌痛和典型的波纹，经临床检查证实。停用他汀类药物改善了他的症状。辛伐他汀治疗恢复，导致他的症状迅速和严重的恢复。症状出现约1年后，患者出现轻度血清学阳性的眼球型重症肌无力，5个月后自行缓解。我们假设他汀类药物暴露加剧了免疫介导的空洞功能破坏。我们没有发现任何他汀类药物介导的RMD的病例。
We report a 53-year-old-man who developed rippling muscle disease (RMD) 2 months after starting simvastatin therapy for hypercholesterolemia. He experienced stiffness, myalgias, and classic rippling, which was confirmed on clinical examination. Discontinuation of the statin improved his symptoms. Simvastatin therapy was resumed and resulted in a prompt and severe return of his symptoms. Approximately 1 year after symptom onset he developed mild seropositive oculobulbar myasthenia gravis, which spontaneously remitted after 5 months. We postulate that an immune-mediated disruption of caveolar function was exacerbated by statin exposure. We are unaware of any previous cases of statin-mediated unmasking of RMD.