Flow correlated percolation during vascular remodeling in growing tumors
Flow correlated percolation during vascular remodeling in growing tumors
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DOI：
10.1103/physrevlett.96.058104
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发表时间：
2006-02-10
影响因子：
8.6
通讯作者：
Bartha, K
中科院分区：
文献类型：
--
作者：
Lee, DS;Rieger, H;Bartha, K
基于生长中的肿瘤和动态演变的血管网络之间的分子相互作用的理论模型描述了正常组织中的规则脉管系统向高度不均匀的肿瘤特异性毛细血管网络的转化。新出现的形态学特征是肿瘤区室化成血管密度、直径和坏死不同的几个区域，与人黑色素瘤的实验数据一致。由于血流严重减少和肿瘤施加的固体应力的组合导致的血管塌陷导致相关的渗透过程，该渗透过程通过流体动力学血管稳定的机制被推向临界状态。
A theoretical model based on the molecular interactions between a growing tumor and a dynamically evolving blood vessel network describes the transformation of the regular vasculature in normal tissues into a highly inhomogeneous tumor specific capillary network. The emerging morphology, characterized by the compartmentalization of the tumor into several regions differing in vessel density, diameter, and necrosis, is in accordance with experimental data for human melanoma. Vessel collapse due to a combination of severely reduced blood flow and solid stress exerted by the tumor leads to a correlated percolation process that is driven towards criticality by the mechanism of hydrodynamic vessel stabilization.