The relationship between antisaccades, smooth pursuit, and executive dysfunction in first-episode schizophrenia
The relationship between antisaccades, smooth pursuit, and executive dysfunction in first-episode schizophrenia
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DOI：
10.1016/j.biopsych.2004.07.002
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发表时间：
2004-10-15
影响因子：
10.6
通讯作者：
Joyce, EM
中科院分区：
文献类型：
--
作者：
Hutton, SB;Huddy, V;Joyce, EM
背景资料：眼科和神经心理学缺陷都被用来支持精神分裂症与前额叶皮质功能障碍有关的假设，但专门研究这些缺陷之间关系的研究产生了一致的结果。方法：我们测量了一大组（n = 109）首发精神分裂症患者和一组匹配的对照组（n = 59），并研究了这些任务的性能和性能的一系列执行任务之间的关系。我们还探讨了这些变量之间的关系和措施的精神病理学在介绍和未经治疗的psycho.Results的持续时间：防accade错误显着相关的空间工作记忆性能。平稳追求增益与任何神经心理学指标无关。有没有可靠的相关性之间的任何oculably变量和措施的精神病理学和持续时间的未治疗，psychiatris.Conclusions：这些研究结果表明，在精神分裂症的工作记忆和antisaccade性能反映了同样的异常前额叶基板和顺利的追求是介导的一个单独的神经异常。
Background: Both oculomotor and neuropsychologic deficits have been used to support the hypothesis that schizophrenia is associated with prefrontal cortex dysfunction, but studies that have specifically investigated the relationships between these deficits have produced in consistent findings.Methods: We measured both smooth pursuit and antisaccade performance in a large group (n = 109) of patients with first episode schizophrenia and a group of matched control subjects (n = 59) and investigated the relationship between performance on these tasks and performance on a range of executive tasks. We additionally explored the relationship between these variables and measures of psychopathology at presentation and duration of untreated psychosis.Results: Antisaccade errors were significantly correlated with spatial working memory performance. Smooth pursuit gain did not correlate with any neuropsychologic measure. There were no reliable correlations between either oculomotor variables and measures of psychopathology and duration of untreated,psychosis.Conclusions: These findings suggest that in schizophrenia working memory and antisaccade performance reflect the same abnormal prefrontal substrates and that smooth pursuit is mediated by a separate neural abnormality.