A role for platelet release of serotonin in the initiation of contact sensitivity.
A role for platelet release of serotonin in the initiation of contact sensitivity.
复制标题
血小板释放血清素在接触敏感性启动中的作用。
DOI：
10.1159/000236958
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发表时间：
1995
影响因子：
2.8
通讯作者：
Matsuda,H
中科院分区：
文献类型：
--
作者：
Askenase,PW;Geba,GP;Levin,J;Ratzlaff,RE;Anderson,GM;Ushio,H;Ptak,W;Matsuda,H
发现接触敏感性（CS）反应是相当正常的耳肿胀，并在5-羟色胺（5-HT）的依赖性肥大细胞缺陷小鼠，导致实验，以确定是否血小板补充肥大细胞作为来源的5-HT在CS。严重的血小板耗竭，因此血液5-HT，抗血小板抗体，强烈抑制CS，特别是在肥大细胞缺陷的小鼠，这表明血小板补充肥大细胞。此外，人血小板在体外致敏与抗（三硝基苯基）IgE，并转移与孤立的迟发效应T细胞一起静脉内，提供CS启动由于本地5-HT释放。类似地，IgE依赖的5-HT体外释放是C依赖的。这些发现确立了抗原特异性血小板释放5-HT在CS启动中的重要性。
Finding contact sensitivity (CS) responses that were fairly normal in ear swelling, and in serotonin (5-HT) dependence in mast-cell-deficient mice, led to experiments to determine whether platelets supplemented mast cells as a source of 5-HT in CS. Severe depletion of platelets, and consequently blood 5-HT, with antiplatelet antibody, strongly inhibited CS, especially in mast-cell-deficient mice, suggesting that platelets supplemented mast cells. Furthermore, human platelets sensitized in vitro with anti-(tri-nitro-phenyl) IgE, and transferred intravenously together with isolated late-acting effector T cells, provided CS initiation due to local 5-HT release. Similar, IgE-dependent in vitro release of 5-HT was C dependent. These findings establish the importance of antigen-specific platelet release of 5-HT in CS initiation.