Relation between number of cardiovascular risk factors/events and noninvasive Doppler ultrasound assessments of aortic compliance
Relation between number of cardiovascular risk factors/events and noninvasive Doppler ultrasound assessments of aortic compliance
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DOI：
10.1161/01.hyp.32.3.565
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发表时间：
1998-09-01
期刊：
影响因子：
8.3
通讯作者：
Gosling, RG
中科院分区：
文献类型：
--
作者：
Lehmann, ED;Hopkins, KD;Gosling, RG
本研究的目的是建立基于“足对足”主动脉脉冲波速度测量的无创多普勒超声评估主动脉顺应性与血管疾病和/或糖尿病患者推测的动脉粥样硬化负荷之间的关系。110例血管疾病和/或糖尿病（动脉病变）患者采用多普勒超声测量了体内主动脉顺应性。记录了这些受试者的人口统计数据以及心血管危险因素和事件的细节。将主动脉顺应性值与51名年龄匹配的健康无症状受试者（对照组）的数据进行比较，数据以平均值+/-SD表示。动脉病变患者年龄为64.1+/-8.4岁，总胆固醇水平为5.9+/-1.1 mmol/L，主动脉顺应性为0.78+/-0.42%/10 mm Hg [1.33 kPa]。大多数动脉病变有2种或2种以上的心血管危险因素和事件：糖尿病（n=41）、高血压（n=45）、吸烟（n=86）、脑血管/短暂性脑缺血事件（n=13）、心肌梗死（n=44）、心绞痛（n=51）和/或周围血管疾病（n=33）。对照组年龄为64.3+/-12.1岁，总胆固醇为6.1+/-1.1 mmol/L，主动脉顺应性为1.14+/-0.46%/10 mm Hg [1.33 kPa] (P
The aim of this study was to establish the relation between noninvasive Doppler ultrasound assessments of aortic compliance, based on "foot-to-foot" aortic pulse wave velocity measurements, and presumed atherosclerotic load in patients with vascular disease and/or diabetes mellitus. One hundred ten patients with vascular disease and/or diabetes mellitus (arteriopaths) underwent measurement of in vivo aortic compliance using Doppler ultrasound. Demographic data on these subjects were recorded along with details of cardiovascular risk factors and events. Aortic compliance values were compared with data from 51 age-matched healthy, asymptomatic subjects putatively free of vascular disease (controls), Data are expressed as mean+/-SD. Arteriopaths were aged 64.1+/-8.4 years and had total cholesterol levels of 5.9+/-1.1 mmol/L, and aortic compliance of 0.78+/-0.42%/10 mm Hg [1.33 kPa]. Most arteriopaths had 2 or more cardiovascular risk factors and events: diabetes (n=41), hypertension (n=45), smoking (n=86), cerebrovascular/ transient ischemic event (n=13), myocardial infarction (n=44), angina (n=51), and/or peripheral vascular disease (n=33). Controls were aged 64.3+/-12.1 years with total cholesterol of 6.1+/-1.1 mmol/L and aortic compliance of 1.14+/-0.46%/10 mm Hg [1.33 kPa] (P