Excitation of rat cutaneous nociceptors by noxious cold.
Excitation of rat cutaneous nociceptors by noxious cold.
复制标题
有毒寒冷刺激大鼠皮肤伤害感受器。
DOI：
10.1016/0304-3940(96)12838-x
复制
发表时间：
1996
影响因子：
2.5
通讯作者：
Kajander,KC
中科院分区：
文献类型：
--
作者：
Simone,DA;Kajander,KC
Electrophysiological recordings were made from mechanosensitive nociceptors innervating hairy skin of the rat hindpaw, and responses evoked by a wide range of noxious cold stimuli (20 to −12°C) were determined. All Aδ and C nociceptors sampled were excited by noxious cold. Response thresholds of Aδ nociceptors were significantly higher (colder stimulus temperatures) than thresholds of C fibers, and many exhibited response thresholds below 0°C. Responses of both classes of nociceptors increased as stimulus temperature decreased. These data demonstrate that Aδ and C nociceptors are excited by a wide range of cold stimuli and suggest that the proportion of cutaneous nociceptors excited by noxious cold has been underestimated in previous studies.
