Scale-up of the rounding process in pelletization by extrusion-spheronization

Scale-up of the rounding process in pelletization by extrusion-spheronization
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DOI:
10.1080/10837450.2019.1621900
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发表时间:
2019-06-19
影响因子:
3.4
通讯作者:
Thommes, Markus
Thommes, Markus
中科院分区:
医学4区
文献类型:
--
作者:
Evers, Maria;Weis, Dominik;Thommes, Markus

文献摘要

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先前描述的湿挤出物滚圆过程的比例模型是不完整的,通常以根据滚圆机直径调整板速度而结束,但忽略给出关于负载或过程持续时间的调整的指导。在这项工作中,现有的扩展模型被扩展为包括负载和处理时间。通过分析板直径为 0.12 m、0.25 m 和 0.38 m 的滚圆机中的最终粒径和形状分布以及各种负载和板速度的圆化动力学,验证了所发现的缩放模型。发现圆周速度是对磨圆动力学的主要影响,而负载和板直径仅显示出较小的影响。更高的圆周速度、更高的负载和更大的滚圆机直径导致滚圆动力学的增加,从而缩短停留时间并增加吞吐量。然而,较低的圆周速度、较低的负载和较小的板直径导致颗粒球形度增加。
Previously described scaling models for the spheronization process of wet extrudates are incomplete, often concluding with an adjustment of the plate speed according to the spheronizer diameter, but neglecting to give guidelines on the adjustment of the load or the process duration. In this work, existing scaling models were extended to include the load and the process time. By analyzing the final particle size and shape distributions as well as the rounding kinetics for various loads and plate speeds in spheronizers with plate diameters of 0.12 m, 0.25 m and 0.38 m, the found scaling model was validated. The peripheral speed was found to be the main influence on the rounding kinetic, while the load and the plate diameter only showed minor influence. Higher peripheral speeds, higher loads and a larger spheronizer diameter led to an increase in rounding kinetic, allowing for shorter residence times and increased throughput. However, lower peripheral speed, lower loads and lower plate diameters led to particles of increased sphericity.