Comparison of clinical, laboratory and radiological characteristics between Chlamydia psittaci and adenovirus pneumonias: a multicenter retrospective study
Comparison of clinical, laboratory and radiological characteristics between Chlamydia psittaci and adenovirus pneumonias: a multicenter retrospective study
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DOI：
10.1016/j.ijid.2022.11.029
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发表时间：
2022-12-09
影响因子：
8.4
通讯作者：
Pan, Pinhua
中科院分区：
文献类型：
--
作者：
Li, Yi;Lin, Fengyu;Pan, Pinhua
目的：鹦鹉热衣原体肺炎是一个重要的全球性公共卫生问题。症状发作和实验室特征可能与其他呼吸道病毒感染（包括腺病毒肺炎）相混淆。我们的目的是确定临床表现的差异，并建立一个简单的诺模图来区分C。方法：我们在10所三级综合医院进行了一项多中心回顾性研究，比较了10所三级综合医院中感染鹦鹉热和腺病毒肺炎的患者。鹦鹉热（n = 78）或腺病毒（n = 102）肺炎。采用多因素Logistic回归模型分析影响冠心病的危险因素。结果：鹦鹉热C.鹦鹉热和腺病毒肺炎表现出某些相似的临床症状，包括发热，呼吸困难和疲劳，但在其他特征上有所不同。多因素Logistic回归分析显示，年龄、性别、神经系统症状、淋巴细胞计数、C反应蛋白水平、双肺病变是C。鹦鹉热肺炎纳入这6个因素后，建立的诺模图在区分肺炎类型方面达到了良好的一致性值（0.949 [95%CI 0.917-0.982]），具有拟合良好的校准曲线。结论：尽管具有相似的临床特征，但将年龄、性别、神经系统症状、淋巴细胞、C反应蛋白水平和双侧肺病变等变量组合成临床上有用的诺模图，用于快速和早期鉴别C。鹦鹉热肺炎源于腺病毒肺炎。这个列线图可能有助于改善治疗和临床结果。第2022章作者（二）由Elsevier Ltd代表国际传染病学会发布。这是一篇开放获取的文章，使用CC BY-NC-ND许可证（http://creativecommons.org/licenses/by-nc-nd/4.0/）
Objectives: Pneumonia caused by Chlamydia psittaci is a significant global public health issue. Symptom onset and laboratory characteristics may be confused with those of other respiratory viral infections, including adenovirus pneumonia. We aimed to determine differences in clinical presentations and establish a simple nomogram to differentiate C. psittaci and adenovirus pneumonias.Methods: We conducted a multicenter retrospective study in 10 tertiary general hospitals to compare patients with either C. psittaci (n = 78) or adenovirus (n = 102) pneumonia. A multivariable logistic regression model was used to identify risk factors of C. psittaci pneumonia that were used to establish a nomogram.Results: C. psittaci and adenovirus pneumonia showed certain similar clinical symptoms, including fever, dyspnea, and fatigue, but differed in other characteristics. The multivariate logistic regression showed that age, sex, nervous system symptoms, lymphocyte count, C-reactive protein level, and bilateral lung lesions were risk factors for C. psittaci pneumonia. After incorporating these six factors, the established nomogram achieved a good concordance value (0.949 [95% CI 0.917-0.982]) in differentiating the types of pneumonia, with well-fitting calibration curves. Conclusion: Despite having similar clinical features, the variables of age, sex, nervous system symptoms, lymphocytes, C-reactive protein levels, and bilateral lung lesions were combined into a clinically useful nomogram for the rapid and early differentiation of C. psittaci pneumonia from adenovirus pneumonia. This nomogram may help improve treatments and clinical outcomes.& COPY; 2022 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )