Histology of the mucosa in sigmoid colon specimens with diverticular disease: observations for the interpretation of sigmoid colonoscopic biopsy specimens.
Histology of the mucosa in sigmoid colon specimens with diverticular disease: observations for the interpretation of sigmoid colonoscopic biopsy specimens.
复制标题
患有憩室病的乙状结肠标本中粘膜的组织学：乙状结肠镜活检标本解释的观察结果。
DOI：
--
复制
发表时间：
1997
影响因子：
3.5
通讯作者：
Ejaz Ahmad
中科院分区：
文献类型：
--
作者：
Neal S. Goldstein;Ejaz Ahmad
我们回顾性检查了100例因憩室炎（DD [憩室病]-憩室炎）切除的乙状结肠切除标本，53例同时患有憩室病（DD-腺癌）的腺癌标本，以及50例未患有DD（仅腺癌）的腺癌标本，以研究DD中发生的粘膜变化。记录这些组织学特征可能有助于解释老年患者乙状结肠结肠镜活检标本的变化。所有DD标本中约90%存在明显的粘膜褶皱。在15%和9%的DD-憩室炎和DD-腺癌标本中，分别存在突出褶皱底部的粘膜淋巴浆细胞炎症增加。11%的DD-憩室炎和4%的DD-腺癌标本在突出的粘膜褶皱表面有脱垂样粘膜异常。在约25%的DD标本中，憩室开口周围淋巴浆细胞炎症轻度增加。所有憩室炎口周围粘膜均有嗜酸性和淋巴浆细胞性炎症。无标本有隐窝变形。憩室病相关炎症可能是偶见于乙状结肠活检标本的轻度片状炎症的原因之一。憩室病也应该被认为是乙状结肠活检标本中粘膜脱垂变化的原因。当粘膜炎症明显增加、隐窝变形或肉芽肿出现时，应考虑其他疾病。DD相关的偶然发现和显著的病理异常之间的区别通常可以通过多个活检标本的采购来进行。
We examined retrospectively 100 sigmoid colon resection specimens removed for diverticulitis (DD [diverticular disease]-diverticulitis), 53 adenocarcinoma specimens that also had diverticulosis (DD-adenocarcinoma), and 50 adenocarcinoma specimens that did not have DD (adenocarcinoma only) to study the mucosal changes that occur in DD. Documenting these histologic features could be helpful in deciphering changes seen in colonoscopic biopsy specimens from the sigmoid colon in older patients. Prominent mucosal folds were present in approximately 90% of all DD specimens. Increased mucosal lymphoplasmacytic inflammation at the bases of the prominent folds was present in 15% and 9% of DD-diverticulitis and DD-adenocarcinoma specimens, respectively. Eleven percent of the DD-diverticulitis and 4% of the DD-adenocarcinoma specimens had prolapselike mucosal abnormalities of the mucosa on the surface of the prominent mucosal folds. Mildly increased lymphoplasmacytic inflammation surrounded the diverticulosis ostia in approximately 25% of all DD specimens. All the diverticulitis ostia had neutrophilic and lymphoplasmacytic inflammation in the surrounding mucosa. No specimens had crypt distortion. Diverticular disease-related inflammation may be one cause of mild patchy inflammation that is occasionally observed in sigmoid colon biopsy specimens. Diverticular disease also should be considered as a cause of mucosal prolapse changes in sigmoid colon biopsy specimens. Other diseases should be considered when markedly increased mucosal inflammation, crypt distortion, or granulomas are present. Distinction between a DD-related incidental finding and a significant pathologic abnormality frequently can be made with the procurement of multiple biopsy specimens.