7T MRI in epilepsy patients with previously normal clinical MRI exams compared against healthy controls
7T MRI in epilepsy patients with previously normal clinical MRI exams compared against healthy controls
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DOI：
10.1371/journal.pone.0213642
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发表时间：
2019-03-19
期刊：
影响因子：
3.7
通讯作者：
Balchandani, Priti
中科院分区：
文献类型：
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作者：
Feldman, Rebecca Emily;Delman, Bradley Neil;Balchandani, Priti
目的比较7T磁共振成像（7T MRI）在局灶性癫痫患者和健康对照者中的应用价值。MRI方案包括整个皮质的高分辨率T1加权、T2加权和磁敏感加权成像序列。图像由两个神经放射科医生，谁是最初盲目的临床数据，然后审查了第二次与知识的癫痫发作zonedizon.ResultsA共25例癫痫的潜在结果。在5名患者中，这些肯定与他们的癫痫有关，通过手术干预证实，在3名患者中，他们共同定位于疑似癫痫发作区，并可能导致癫痫发作。在7例患者中，影像学检查结果共同定位于疑似癫痫发作区，但不是确切原因，10例患者的皮质病变具有致癫痫潜能，但未定位于疑似癫痫发作区。在癫痫患者和健康对照组中发现了多个不确定意义的其他发现。磁敏感加权成像序列是在指导更有针对性的检查其他结构的图像，并帮助在识别皮层lesions.SignificanceInformation揭示了提高分辨率和增强对比度所提供的7T成像是有价值的癫痫患者的非病灶在临床场强的非侵入性识别病变。
ObjectiveTo compare by 7 Tesla (7T) magnetic resonance imaging (MRI) in patients with focal epilepsy who have non-lesional clinical MRI scans with healthy controls.Methods37 patients with focal epilepsy, based on clinical and electroencephalogram (EEG) data, with non-lesional MRIs at clinical field strengths and 21 healthy controls were recruited for the 7T imaging study. The MRI protocol consisted of high resolution T-1-weighted, T-2-weighted and susceptibility weighted imaging sequences of the entire cortex. The images were read by two neuroradiologists, who were initially blind to clinical data, and then reviewed a second time with knowledge of the seizure onset zone.ResultsA total of 25 patients had findings with epileptogenic potential. In five patients these were definitely related to their epilepsy, confirmed through surgical intervention, in three they co-localized to the suspected seizure onset zone and likely caused the seizures. In seven patients the imaging findings co-localized to the suspected seizure onset zone but were not the definitive cause, and ten had cortical lesions with epileptogenic potential that did not localize to the suspected seizure onset zone. There were multiple other findings of uncertain significance found in both epilepsy patients and healthy controls. The susceptibility weighted imaging sequence was instrumental in guiding more targeted inspection of the other structural images and aiding in the identification of cortical lesions.SignificanceInformation revealed by the improved resolution and enhanced contrast provided by 7T imaging is valuable in noninvasive identification of lesions in epilepsy patients who are non-lesional at clinical field strengths.