Next step in the ongoing arms race between myxoma virus and wild rabbits in Australia is a novel disease phenotype
Next step in the ongoing arms race between myxoma virus and wild rabbits in Australia is a novel disease phenotype
复制标题
DOI：
10.1073/pnas.1710336114
复制
发表时间：
2017-08-29
影响因子：
11.1
通讯作者：
Read, Andrew F.
中科院分区：
文献类型：
--
作者：
Kerr, Peter J.;Cattadori, Isabella M.;Read, Andrew F.
在宿主-病原体的军备竞赛中，宿主抗性的增加促使病原体的反适应，但这种反适应的性质很少在实验室模型之外直接观察到。最好的记录领域的例子是粘液瘤病毒（MYXV）在欧洲兔子的共同进化。为了了解澳大利亚的MYXV如何在对多发性粘液瘤病的遗传抗性的强烈选择下在野兔中继续进化，我们在没有抗性的实验室兔子中比较了20世纪50年代和90年代的祖先MYXV和病毒分离株的表型。引人注目的是，与20世纪50年代的病毒不同，20世纪90年代的大多数病毒分离株诱导了一种类似于感染性休克的高致命性免疫崩溃综合征。因此，在这种典型的物种跳跃后共同进化的情况下，病毒在面对广泛的宿主抗性时会进一步升级。
In host-pathogen arms races, increases in host resistance prompt counteradaptation by pathogens, but the nature of that counteradaptation is seldom directly observed outside of laboratory models. The best-documented field example is the coevolution of myxoma virus (MYXV) in European rabbits. To understand how MYXV in Australia has continued to evolve in wild rabbits under intense selection for genetic resistance to myxomatosis, we compared the phenotypes of the progenitor MYXV and viral isolates from the 1950s and the 1990s in laboratory rabbits with no resistance. Strikingly, and unlike their 1950s counterparts, most virus isolates from the 1990s induced a highly lethal immune collapse syndrome similar to septic shock. Thus, the next step in this canonical case of coevolution after a species jump has been further escalation by the virus in the face of widespread host resistance.