Measuring and using light in the melanopsin age.
Measuring and using light in the melanopsin age.
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DOI：
10.1016/j.tins.2013.10.004
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发表时间：
2014-01
影响因子：
15.9
通讯作者：
Brainard GC
中科院分区：
文献类型：
--
作者：
Lucas RJ;Peirson SN;Berson DM;Brown TM;Cooper HM;Czeisler CA;Figueiro MG;Gamlin PD;Lockley SW;O'Hagan JB;Price LL;Provencio I;Skene DJ;Brainard GC
光是调节昼夜节律、激素和行为系统的有力刺激。此外，光疗法对某些情感障碍，睡眠问题和昼夜节律紊乱有效。光的这些生物学和行为效应受到眼睛中不同的光感受器的影响，除了常规的视杆细胞和视锥细胞之外，还受到含有固有光敏视网膜神经节细胞（ipRGC）的黑视蛋白的影响。我们总结了这种新描述的感觉通路的神经生理学，并考虑光的测量，生产和应用的影响。一种新的光测量策略，考虑到复杂的光感受输入这些非视觉反应，提出了供研究人员使用，并为监管机构，照明制造商，设计师和工程师提供人工/建筑照明的简单建议。
Light is a potent stimulus for regulating circadian, hormonal, and behavioral systems. In addition, light therapy is effective for certain affective disorders, sleep problems, and circadian rhythm disruption. These biological and behavioral effects of light are influenced by a distinct photoreceptor in the eye, melanopsin containing intrinsically photosensitive retinal ganglion cells (ipRGCs), in addition to the conventional rods and cones. We summarize the neurophysiology of this newly described sensory pathway and consider implications for the measurement, production and application of light. A new light-measurement strategy taking account of the complex photoreceptive input to these non-visual responses is proposed for use by researchers, and simple suggestions for artificial/architectural lighting are provided for regulatory authorities, lighting manufacturers, designers and engineers.