Mouse Models to Study Secondary Cancer Prevention.
Mouse Models to Study Secondary Cancer Prevention.
复制标题
研究二级癌症预防的小鼠模型。
DOI：
10.1007/978-1-0716-2014-4_16
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Zhang,Yu
中科院分区：
文献类型：
--
作者：
Li,Le;Chandra,Vidhi;McAllister,Florencia;Zhang,Yu
二级预防是在临床体征或症状出现之前发现早期复发、局部或全身转移的一系列程序。我们描述了一个小鼠模型，原位胰腺肿瘤植入后，远端胰腺切除术。生物发光成像和MRI可用于筛查切除后的原发肿瘤复发和继发癌的发展。不同类型的外科手术、化疗或免疫疗法可用于降低原发性癌症的转移潜力。该模型已被证明是安全且易于建立的，可以模拟临床情况，扩大了研究肿瘤切除和辅助或新辅助治疗对癌症二级预防的影响的视角。
Secondary prevention is a set of procedures involved in discovering early recurrence, local or systemic metastasis before the clinical signs or symptoms. We describe a mouse model with orthotopic pancreatic tumor implantation followed by distal pancreatectomy. The bioluminescence imaging and MRI could be used for screening the resected primary tumor recurrence and secondary cancer development. Different types of surgical procedures, chemotherapy, or immunotherapy can be engaged in reducing the metastasis potential of primary cancers. This model has been proved to be safe and easy to establish, which can mimic the clinical scenario and expand perspectives for studying the effects of tumor resection and adjuvant or neoadjuvant therapy on secondary cancer prevention.
影响因子：
29.4
作者：
Guerlevik, Engin;Fleischmann-Mundt, Bettina;Kuehnel, Florian
通讯作者：
Kuehnel, Florian