Context-specific effects of estradiol on spatial learning and memory in the zebra finch.
Context-specific effects of estradiol on spatial learning and memory in the zebra finch.
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雌二醇对斑胸草雀空间学习和记忆的特定影响。
DOI：
10.1016/j.nlm.2012.12.005
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发表时间：
2013
影响因子：
2.7
通讯作者：
Schlinger,BA
中科院分区：
文献类型：
--
作者：
Rensel,MA;Salwiczek,L;Roth,J;Schlinger,BA
众所周知，情绪会影响认知功能，包括空间学习和记忆，研究主要集中在啮齿动物模型上。雌激素可以作为神经雌激素在外周或中枢产生，神经雌激素在记忆过程中的具体作用尚未得到解决。许多鸣禽具有显着的空间记忆能力，也表达了大量的雌激素合成酶芳香化酶在海马，这表明当地产生的雌激素可能会促进收购或检索的空间记忆在这些鸟类。我们研究了雌二醇对斑胸草雀空间记忆的影响，在三种情况下：辨别训练后的检索，熟悉后的检索，但没有歧视的训练，和记忆的获得，使用雌二醇植入物和口服芳香酶抑制剂法倔唑（FAD）的组合。当雌二醇的产生被阻止时，在这两种情况下空间记忆的提取都会受到损害。然而，当雌二醇的产生受到抑制时，空间记忆的获得会增强，而雌二醇的替代会削弱空间记忆的获得。这些结果为雌二醇在鸣禽空间记忆中的特定作用提供了证据，这些结果与一些哺乳动物研究结果雅阁，但尚未在鸟类中观察到。
Estradiol is known to impact cognitive function including spatial learning and memory, with studies focused largely on rodent models. Estrogens can be produced peripherally or centrally as neuroestrogens, and the specific role for neuroestrogens in memory processes remains unresolved. Many songbirds possess remarkable spatial memory capabilities and also express the estrogen synthetic enzyme aromatase abundantly in the hippocampus, suggesting that locally-produced estrogens may promote the acquisition or retrieval of spatial memories in these birds. We examined the effect of estradiol on spatial memory in three contexts in the zebra finch: retrieval after discrimination training, retrieval after familiarization but without discrimination training, and memory acquisition, using a combination of estradiol implants and oral dosing with the aromatase inhibitor fadrozole (FAD). Retrieval of spatial memory in both contexts was impaired when estradiol production was blocked. However, spatial memory acquisition was enhanced when estradiol production was inhibited whereas estradiol replacement impaired acquisition. These results provide evidence for a context-specific role of estradiol in songbird spatial memory, results that find accord with some mammalian studies but have not yet been observed in birds.