MRI-Guided focused ultrasound: Methodology and applications
MRI-Guided focused ultrasound: Methodology and applications
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DOI：
10.1109/tmi.2006.873296
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发表时间：
2006-06-01
影响因子：
10.6
通讯作者：
Moonen, Chrit T. W.
中科院分区：
文献类型：
--
作者：
Hokland, Steffen L.;Pedersen, Michael;Moonen, Chrit T. W.
聚焦超声非常适合诱导无创局部热疗。由于磁共振成像 (MRI) 可以用于无创地获取实时温度图，因此这两种技术的结合为肿瘤学研究提供了巨大的优势。实时识别目标区域并准确控制治疗过程中的温度演变现已成为可能。最近，这种独特的技术已经证明了病理组织的热消融、使用热敏微载体的局部药物递送以及使用热敏启动子的受控转基因表达。基于这些实验，聚焦超声和 MRI 测温相结合为未来的肿瘤诊断和治疗带来了希望。在本文中，我们回顾了一些最近的方法学进展以及使用这种方法的实验和首次临床研究。
Focused ultrasound is very well suited for inducing noninvasive local hyperthermia. Since magnetic resonance imaging (MRI) may he employed to obtain real-time temperature maps noninvasively the combination of these two technologies offers great advantages specifically aimed toward oncological studies. Real-time identification of the target region and accurate control of the temperature evolution during the treatment has now become possible. Thermal ablation of pathological tissue, local drug delivery using thermosensitive micro-carriers and controlled transgene expression using thermosensitive promoters have recently been demonstrated with this unique technology. Based on these experiments combined focused ultrasound and MRI thermometry holds promise for future oncological diagnostics and treatment. In this paper, we review some of the recent methodological developments as well as experimental and first clinical studies using this approach.