Nursing induces a biphasic release of prolactin in rhesus monkeys.
Nursing induces a biphasic release of prolactin in rhesus monkeys.
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护理会诱导恒河猴催乳素的双相释放。
DOI：
10.1210/endo-112-2-558
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发表时间：
1983
期刊：
影响因子：
4.8
通讯作者：
J. D. Neill
中科院分区：
文献类型：
--
作者：
L. Frawley;J. Mulchahey;J. D. Neill
本文观察了4只清醒的、未受约束的恒河猴（产后20--46天）在体外留置心导管后，不同护理措施对血清催乳素（PRL）水平的影响。在实验当天，婴儿被转移到一个单独的房间9.5小时。在婴儿返回前1小时和返回后3小时，以频繁的间隔从母亲处收集用于PRL测定的血液样品。在所有情况下，在母亲和婴儿团聚后10分钟内观察到乳头的剧烈吸吮，并导致血清PRL从初始值7.4 +/- 0.5 ng/ml（平均值+/- SEM）升高至90分钟时的峰值339.7 +/- 56.1 ng/ml。从个别动物的分泌模式分析表明，PRL释放是双相的。在第一阶段，即婴儿返回后10- 50分钟内开始，持续20- 50分钟，血清PRL浓度以0.47 ng/ml的平均速率升高。第二阶段持续20--40分钟，血清PRL以20倍的速率升高（10.57 ng/ml）。最大持续水平。这种不寻常的模式是否发生PRL分泌的神经内分泌相互作用独特的这种物种的结果，或只是反映了延长和分区的分泌过程中常见的其他哺乳动物仍有待确定。
The effect of nursing on serum PRL levels was studied in four conscious unrestrained rhesus monkeys (20--46 days postpartum) fitted previously with exteriorized cardiac catheters. On the day of an experiment, the infant was transferred to a separate room for 9.5 h. Blood samples for PRL assay were collected from the mother at frequent intervals for 1 h before and 3 h after returning the infant. In all instances, vigorous suckling of the nipple was observed within 10 min of reuniting mother and infant and resulted in an elevation of serum PRL from an initial value of 7.4 +/- 0.5 ng/ml (mean +/- SEM) to a peak at 90 min of 339.7 +/- 56.1 ng/ml. Analysis of secretory patterns from individual animals revealed that PRL release was biphasic. During phase I, which began within 10--50 min of returning the infants and lasted for 20--50 min, serum PRL concentrations increased at an average rate of 0.47 ng/ml . min. This was followed by phase II, lasting 20--40 min, during which serum PRL rose at a 20-fold greater rate (10.57 ng/ml . min) to sustained maximum levels. Whether this unusual pattern of PRL secretion occurs as a consequence of neuroendocrine interactions unique to this species or simply reflects the prolongation and partitioning of a secretory process common to other mammals remains to be determined.
有证据表明，促甲状腺素释放激素和下丘脑催乳素释放因子可能在哺乳大鼠催乳素的释放中发挥作用。
影响因子：
4.8
作者：
Grosvenor,CE;Mena,F
通讯作者：
Mena,F