Mild, calcium catalysed Beckmann rearrangements
Mild, calcium catalysed Beckmann rearrangements
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DOI：
10.1039/c7cc09491d
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发表时间：
2018-01-18
影响因子：
4.9
通讯作者：
McLaughlin, M. G.
中科院分区：
文献类型：
--
作者：
Kiely-Collins, H. J.;Sechi, I.;McLaughlin, M. G.
一种温和的钙催化的贝克曼重排已经实现，它放弃了与转化相关的更传统的严酷反应条件。该催化剂体系对与天然产物合成和药物化学相关的多种官能团具有耐受性，并且对该反应的合成用途也进行了研究。进行了初步的机理研究，以了解进入的亲核试剂的性质，并描述了可能的反应途径。
A mild calcium catalysed Beckmann rearrangement has been realised, which forgoes the more traditional harsh reactions conditions associated with the transformation. The catalyst system is shown to be tolerant towards a wide variety of functional groups relevant to natural product synthesis and medicinal chemistry and the synthetic utility of the reaction has also been investigated. A preliminary mechanistic investigation was performed to understand the nature of the incoming nucleophile and a possible reaction pathway is described.