Proteomimetics as protein-inspired scaffolds with defined tertiary folding patterns.
Proteomimetics as protein-inspired scaffolds with defined tertiary folding patterns.
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蛋白质模拟物作为具有明确三级折叠模式的蛋白质启发支架。
DOI：
10.1038/s41557-020-0420-9
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发表时间：
2020-04
期刊：
影响因子：
21.8
通讯作者：
Grossmann TN
中科院分区：
文献类型：
--
作者：
Horne WS;Grossmann TN
蛋白质已经进化成一个可变的平台，提供了不同形状、大小和功能的分子。几十年来，这些特征一直激励着化学家们寻找具有改进或新特性的蛋白质的人工模拟物。这些工作主要集中在小的蛋白质片段上，通常是孤立的二级结构；然而，最近人们对模拟更大、更复杂的三级褶皱的人造分子的设计越来越感兴趣。在这方面，我们将这些试剂定义为“蛋白质组学”，并讨论了该领域的最新进展。蛋白质组学可以分为三类：(1)具有改变天然线性链拓扑结构的侧链功能的蛋白质结构域；(2)多肽主链的化学组成部分被改变的蛋白质结构域；(3)完全由非天然单体单元组成的蛋白质样折叠结构域。我们给出了这些蛋白质组学方法的概述，并概述了该领域面临的剩余挑战。
Proteins have evolved as a variable platform that provides access to molecules with diverse shapes, sizes, and functions. These features have inspired chemists for decades to seek artificial mimetics of proteins with improved or novel properties. Such work has focused primarily on small protein fragments, often isolated secondary structures; however, there has lately been a growing interest in the design of artificial molecules that mimic larger, more complex tertiary folds. In this Perspective, we define these agents as “proteomimetics” and discuss the recent advances in the field. Proteomimetics can be divided into three categories: (1) protein domains with side chain functionality that alters the native linear chain topology, (2) protein domains in which the chemical composition of the polypeptide backbone has been partially altered, and (3) protein-like folded architectures that are composed entirely of non-natural monomer units. We give an overview of these proteomimetic approaches and outline remaining challenges facing the field.
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影响因子：
21.8
作者：
通讯作者：
--
影响因子：
21.8
作者：
Chandramouli, Nagula;Ferrand, Yann;Huc, Ivan
通讯作者：
Huc, Ivan
影响因子：
15
作者：
Chapman, E;Thorson, JS;Schultz, PG
通讯作者：
Schultz, PG
DOI：
10.1073/pnas.1710695114
发表时间：
2017-10-10
影响因子：
11.1
作者：
Dang, Bobo;Wu, Haifan;DeGrado, William F.
通讯作者：
DeGrado, William F.
影响因子：
15
作者：
Becart, Diane;Diemer, Vincent;Guichard, Gilles
通讯作者：
Guichard, Gilles