Degeneration of cardiac sympathetic nerve begins in the early disease process of Parkinson's disease
Degeneration of cardiac sympathetic nerve begins in the early disease process of Parkinson's disease
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DOI：
10.1111/j.1750-3639.2006.00032.x
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发表时间：
2007-01-01
期刊：
影响因子：
6.4
通讯作者：
Takahashi, Hitoshi
中科院分区：
文献类型：
--
作者：
Orimo, Satoshi;Takahashi, Atsushi;Takahashi, Hitoshi
据报道，在帕金森病（PD）的早期阶段，[I-123] MIBG心肌显像显示心脏摄取间碘苄基胍（MIBG）减少，提示心脏交感神经参与了PD的早期发病过程。为了证实这一点，我们使用针对酪氨酸羟化酶（TH）和神经丝（NF）的抗体，对20例偶然路易体病（ILBD）患者的心脏组织、交感神经节和延髓进行了免疫组织化学检查，这被认为是PD的症状前阶段。20例ILBD患者和对照组中10例心外膜神经束免疫反应性神经纤维保存完好。相比之下，6名受试者的th免疫反应性神经纤维几乎消失，20名ILBD患者中的4名中度减少。在检查的任何ILBD患者中均未检测到迷走背核和交感神经节的神经元细胞损失。这些结果表明，心脏交感神经的退行性变始于PD的早期疾病过程，发生在迷走背核神经元细胞丢失之前。
Decreased cardiac uptake of meta-iodobenzylguanidine (MIBG) on [I-123] MIBG myocardial scintigraphy has been reported in the early stages of Parkinson's disease (PD), which suggests involvement of the cardiac sympathetic nerve in the early disease process of PD. For confirmation, we immunohistochemically examined cardiac tissue, sympathetic ganglia and medulla oblongata of 20 patients with incidental Lewy body disease (ILBD), which is thought to be a presymptomatic stage of PD, and 10 control subjects, using antibodies against tyrosine hydroxylase (TH) and neurofilament (NF). Immunoreactive nerve fibers of fascicles in the epicardium were well preserved in 10 of the 20 patients with ILBD and in the control subjects. In contrast, TH-immunoreactive nerve fibers had nearly disappeared in six subjects and were moderately decreased in four of the 20 patients with ILBD. Neuronal cell loss in the dorsal vagal nucleus and the sympathetic ganglia was not detectable in any of the ILBD patients examined. These findings suggest that degeneration of the cardiac sympathetic nerve begins in the early disease process of PD and that it occurs before neuronal cell loss in the dorsal vagal nucleus.