Psychiatric comorbidity in children and adolescents with reading disability.
Psychiatric comorbidity in children and adolescents with reading disability.
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DOI：
10.1111/1469-7610.00691
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发表时间：
2000-11
期刊：
影响因子：
--
通讯作者：
E. Willcutt;B. Pennington
中科院分区：
文献类型：
--
作者：
E. Willcutt;B. Pennington
本研究调查了阅读障碍（RD）和内化和外化精神病理学之间的关联，在一个大的社区样本的双胞胎（N = 209）和没有RD（N = 192）。主要目的是澄清RD和共病精神病理学之间的关系，以测试RD的行为相关性的性别差异，并测试是否常见的家庭影响有助于RD和其他疾病之间的关联。结果表明，个人与RD表现出显着更高的利率比个人没有RD的所有内化和外化障碍。然而，逻辑回归分析表明，RD是没有显着相关的侵略，犯罪，对立违抗性障碍，或行为障碍的症状后，控制RD和ADHD之间的显着关系。与此相反，RD和焦虑和抑郁症状之间的关系仍然显着，即使在控制共病ADHD，这表明内化困难可能是特别与RD。性别差异的分析表明，RD和内化症状之间的显着关系主要限于女孩，而RD和外化的精神病理学之间的关联更强的男孩。最后，初步的病因学分析表明，共同的家族因素使RD先证者和他们的非RD兄弟姐妹表现出外化行为，而内在化行为学的升高仅限于RD个体。
This study investigated the association between reading disability (RD) and internalizing and externalizing psychopathology in a large community sample of twins with (N = 209) and without RD (N = 192). The primary goals were to clarify the relation between RD and comorbid psychopathology, to test for gender differences in the behavioral correlates of RD, and to test if common familial influences contributed to the association between RD and other disorders. Results indicated that individuals with RD exhibited significantly higher rates of all internalizing and externalizing disorders than individuals without RD. However, logistic regression analyses indicated that RD was not significantly associated with symptoms of aggression, delinquency, oppositional defiant disorder, or conduct disorder after controlling for the significant relation between RD and ADHD. In contrast, relations between RD and symptoms of anxiety and depression remained significant even after controlling for comorbid ADHD, suggesting that internalizing difficulties may be specifically associated with RD. Analyses of gender differences indicated that the significant relation between RD and internalizing symptoms was largely restricted to girls, whereas the association between RD and externalizing psychopathology was stronger for boys. Finally, preliminary etiological analyses suggested that common familial factors predispose both probands with RD and their non-RD siblings to exhibit externalizing behaviors, whereas elevations of internalizing symptomatology are restricted to individuals with RD.