Meningococcal Carriage Following a Vaccination Campaign With MenB-4C and MenB-FHbp in Response to a University Serogroup B Meningococcal Disease Outbreak-Oregon, 2015-2016
Meningococcal Carriage Following a Vaccination Campaign With MenB-4C and MenB-FHbp in Response to a University Serogroup B Meningococcal Disease Outbreak-Oregon, 2015-2016
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DOI：
10.1093/infdis/jix446
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发表时间：
2017-11-01
影响因子：
6.4
通讯作者：
Acosta, Anna
中科院分区：
文献类型：
--
作者：
McNamara, Lucy A.;Thomas, Jennifer Dolan;Acosta, Anna
背景关于血清群B脑膜炎球菌（MenB）疫苗MenB-FHbp和MenB-4 C对脑膜炎球菌携带和牛群保护的影响，数据有限。因此，我们评估了2015年针对大学血清群B脑膜炎球菌病爆发的MenB疫苗接种运动后的脑膜炎球菌携带情况。在11个月的4次携带调查期间，推荐接种疫苗的学生方便样本提供了口咽拭子标本并完成了问卷调查。通过实时聚合酶链反应分析、玻片凝集和全基因组测序对分离株进行检测。通过大学记录和国家免疫登记处核实疫苗接种史。共分析了来自3802名独特参与者的4225份口咽拭子标本。总脑膜炎球菌和基因型血清群B携带流行率的抽样学生是稳定的，在每一轮分别为11%-17%和1.2%-2.4%，没有参与者携带爆发菌株。1-3剂MenB-FHbp和1-2剂MenB-4C均与总携带率或血清群B携带率降低无关。虽然很少有参与者完成了完整的MenB疫苗接种系列，限制了分析能力，但这些数据表明MenB-FHbp和MenB-4C对脑膜炎球菌携带没有大的快速影响，并且不太可能在疫情应对的背景下提供牛群保护。
Background. Limited data exist on the impact of the serogroup B meningococcal (MenB) vaccines MenB-FHbp and MenB-4C on meningococcal carriage and herd protection. We therefore assessed meningococcal carriage following a MenB vaccination campaign in response to a university serogroup B meningococcal disease outbreak in 2015.Methods. A convenience sample of students recommended for vaccination provided oropharyngeal swab specimens and completed questionnaires during 4 carriage surveys over 11 months. Isolates were tested by real-time polymerase chain reaction analysis, slide agglutination, and whole-genome sequencing. Vaccination history was verified via university records and the state immunization registry.Results. A total of 4225 oropharyngeal swab specimens from 3802 unique participants were analyzed. Total meningococcal and genotypically serogroup B carriage prevalence among sampled students were stable, at 11%-17% and 1.2%-2.4% during each round, respectively; no participants carried the outbreak strain. Neither 1-3 doses of MenB-FHbp nor 1-2 doses of MenB-4C was associated with decreased total or serogroup B carriage prevalence.Conclusions. While few participants completed the full MenB vaccination series, limiting analytic power, these data suggest that MenB-FHbp and MenB-4C do not have a large, rapid impact on meningococcal carriage and are unlikely to provide herd protection in the context of an outbreak response.