Activity in posterior parietal cortex is correlated with the relative subjective desirability of action
Activity in posterior parietal cortex is correlated with the relative subjective desirability of action
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DOI：
10.1016/j.neuron.2004.09.009
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发表时间：
2004-10-14
期刊：
影响因子：
16.2
通讯作者：
Glimcher, PW
中科院分区：
文献类型：
--
作者：
Dorris, MC;Glimcher, PW
行为研究表明，做出决定涉及代表所有可用动作的总体需求，然后选择最可取的动作。生理研究提出，顶叶皮层中的神经元在选择执行运动方面发挥了作用。为了检验这些顶叶神经元编码进行特定运动的主观需求的假设，我们利用了纳什的游戏理论平衡，在此期间，多种动作的主观可取性对于人类参与者来说应该是平等的。在战略游戏中衡量的行为表明，像人类的选择一样，猴子的选择是由主观可取性的指导。在这些条件下，顶叶皮层中的活性与动作的相对主观可取性相关，与奖励幅度，奖励概率和与每个动作相关的响应概率的特定组合无关。这些观察结果可能有助于将有关后顶皮层的许多最新发现置于一个共同的概念框架中。
Behavioral studies suggest that making a decision involves representing the overall desirability of all available actions and then selecting that action that is most desirable. Physiological studies have proposed that neurons in the parietal cortex play a role in selecting movements for execution. To test the hypothesis that these parietal neurons encode the subjective desirability of making particular movements, we exploited Nash's game theoretic equilibrium, during which the subjective desirability of multiple actions should be equal for human players. Behavior measured during a strategic game suggests that monkeys' choices, like those of humans, are guided by subjective desirability. Under these conditions, activity in the parietal cortex was correlated with the relative subjective desirability of actions irrespective of the specific combination of reward magnitude, reward probability, and response probability associated with each action. These observations may help place many recent findings regarding the posterior parietal cortex into a common conceptual framework.