Signals for Previous Goal Choice Persist in the Dorsomedial, but Not Dorsolateral Striatum of Rats
Signals for Previous Goal Choice Persist in the Dorsomedial, but Not Dorsolateral Striatum of Rats
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DOI：
10.1523/jneurosci.2422-12.2013
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发表时间：
2013-01-02
影响因子：
5.3
通讯作者：
Jung, Min Whan
中科院分区：
文献类型：
--
作者：
Kim, Hoseok;Lee, Daeyeol;Jung, Min Whan
皮质-基底神经节网络已被提出由服务不同功能的平行回路组成。然而，处理后的信息内容在不同的循环中是如何变化的，以及它与每个循环的功能有什么关系，目前还不清楚。我们通过比较执行动态觅食任务的大鼠背外侧纹状体（感觉运动纹状体）和背内侧纹状体（联想纹状体）的神经元活动来研究这个问题，背外侧纹状体分别与习惯性和目标导向的行动选择有关。这两个区域为动物的目标选择及其结果传递了重要的神经信号。此外，这两个区域在动物选择目标前和动物选择结果后传递的行动价值的神经信号水平相似。然而，在动物选择行为的神经信号的持久性方面发现了显著的差异。动物目标选择的信号一直存在于背内侧纹状体，直到动物的下一个目标选择的结果被揭示，而它们在背外侧纹状体中迅速消散。这些持续的选择信号可能用于连接时间不连续的反应及其在背内侧纹状体中的结果，从而有助于其在目标导向的行动选择中的作用。
The cortico-basal ganglia network has been proposed to consist of parallel loops serving distinct functions. However, it is still uncertain how the content of processed information varies across different loops and how it is related to the functions of each loop. We investigated this issue by comparing neuronal activity in the dorsolateral (sensorimotor) and dorsomedial (associative) striatum, which have been linked to habitual and goal-directed action selection, respectively, in rats performing a dynamic foraging task. Both regions conveyed significant neural signals for the animal's goal choice and its outcome. Moreover, both regions conveyed similar levels of neural signals for action value before the animal's goal choice and chosen value after the outcome of the animal's choice was revealed. However, a striking difference was found in the persistence of neural signals for the animal's chosen action. Signals for the animal's goal choice persisted in the dorsomedial striatum until the outcome of the animal's next goal choice was revealed, whereas they dissipated rapidly in the dorsolateral striatum. These persistent choice signals might be used for causally linking temporally discontiguous responses and their outcomes in the dorsomedial striatum, thereby contributing to its role in goal-directed action selection.