Chronic vitamin E treatment prevents defective endothelium-dependent relaxation in diabetic rat aorta
Chronic vitamin E treatment prevents defective endothelium-dependent relaxation in diabetic rat aorta
复制标题
长期维生素 E 治疗可预防糖尿病大鼠主动脉内皮依赖性舒张缺陷
DOI：
10.1007/bf00400609
复制
发表时间：
1995
期刊：
影响因子：
8.2
通讯作者：
N. Cameron
中科院分区：
文献类型：
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作者：
A. Keegan;H. Walbank;M. Cotter;N. Cameron
我们观察了链脲佐菌素诱导的糖尿病大鼠2个月后主动脉舒张和收缩的影响。另一组糖尿病患者从糖尿病诱导开始，在饮食中补充1%的维生素e。糖尿病导致苯肾上腺素预收缩主动脉对乙酰胆碱的最大内皮依赖性松弛减少26.5% （p<0.001）。维生素E处理降低了64.3% (p<0.01)；与非糖尿病大鼠相比，最大松弛没有明显改变。维生素E对非糖尿病大鼠乙酰胆碱诱导的松弛无明显影响。糖尿病或治疗没有显著改变乙酰胆碱敏感性。血管平滑肌对一氧化氮的非依赖性松弛反应不受糖尿病或维生素E治疗的影响。糖尿病患者服用苯肾上腺素后最大收缩反应降低35.4% (p<0.05)，维生素E治疗对最大收缩反应无影响。数据表明，糖尿病中一氧化氮介导的内皮依赖性松弛的慢性缺陷主要取决于活性氧的过度活性。用维生素E治疗增加自由基清除特异性保护血管内皮，尽管它对血管平滑肌收缩反应的缺陷没有影响。
SummaryWe examined the effect in rats of 2 months of streptozotocin-induced diabetes mellitus on relaxation and contraction of aortas in vitro. A further diabetic group was treated from time of diabetes induction with a 1% dietary supplement of vitamin E. Diabetes caused a 26.5% deficit (p<0.001) in maximum endothelium-dependent relaxation to acetylcholine in phenylephrine-precontracted aortas. This was 64.3% attenuated (p<0.01) by vitamin E treatment; maximum relaxation was not significantly altered compared to non-diabetic rats. Vitamin E treatment of non-diabetic rats did not significantly affect acetylcholine-induced relaxation. Diabetes or treatment did not significantly alter acetylcholine sensitivity. Endothelium-independent relaxation response to glyceryl trinitrate was not affected by diabetes or vitamin E treatment, indicating that vascular smooth muscle responses to nitric oxide remained unaltered. There was a 35.4% reduction in the maximum contractile response to phenylephrine with diabetes (p<0.05) which was unaffected by vitamin E treatment. The data suggest that the chronic deficit in nitric oxide-mediated endothelium-dependent relaxation in diabetes depends largely upon excess activity of reactive oxygen species. Treatment with vitamin E to increase free radical scavenging specifically protected vascular endothelium although it had no effect on deficits in vascular smooth muscle contractile responses.
影响因子：
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作者：
NAGAO, T;ILLIANO, S;VANHOUTTE, PM
通讯作者：
VANHOUTTE, PM