Intracerebral haemorrhage: mechanisms of injury and therapeutic targets.
Intracerebral haemorrhage: mechanisms of injury and therapeutic targets.
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DOI：
10.1016/s1474-4422(12)70104-7
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发表时间：
2012-08
期刊：
影响因子：
--
通讯作者：
Xi G
中科院分区：
文献类型：
--
作者：
Keep RF;Hua Y;Xi G
脑出血（ICH）约占所有卒中的10-15%。ICH与高死亡率和发病率相关，目前尚无针对该疾病的成功III期临床试验。在过去的六年中，关注ICH的临床前和临床研究数量大幅增加。在可用于研究ICH的动物模型和我们对出血后脑损伤机制的理解方面，已经取得了重大进展。这导致了几个治疗目标的确定，现在正在进行临床试验。除了过去和目前的临床试验的信息，这些进展在本次审查中进行了描述。许多前者是基于非常有限的临床前数据和可能的指导方针的性质，证明进行临床前的结果进行了讨论。
Intracerebral haemorrhage (ICH) accounts for about 10–15% of all strokes. ICH is associated with high mortality and morbidity and there has been no successful Phase III clinical trial for this condition. The last six years has seen a great increase in the number of pre-clinical and clinical studies focused on ICH. There have been significant advances in the animal models available to study ICH and in our understanding of the mechanisms underlying brain injury following haemorrhage. This has led to the identification of several therapeutic targets that are now being pursued into clinical trials. These advances are described in this review in addition to information on past and current clinical trials. Many of the former were based on very limited pre-clinical data and possible guidelines on the nature of pre-clinical results that justify proceeding to the clinic are discussed.