Development, Homeostasis, and Functions of Intestinal Intraepithelial Lymphocytes.
Development, Homeostasis, and Functions of Intestinal Intraepithelial Lymphocytes.
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DOI：
10.4049/jimmunol.1701704
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发表时间：
2018-04-01
期刊：
影响因子：
--
通讯作者：
Olivares-Villagómez D
中科院分区：
文献类型：
--
作者：
Van Kaer L;Olivares-Villagómez D
肠道不断暴露于共生微生物、食物和环境因子中，也是许多病原体的主要入口。肠道微生物入侵的一个关键防御机制是单层上皮细胞，它将肠道腔与下层组织分开。肠上皮的屏障功能是由肠道免疫系统的细胞和可溶性因子支持的。其中主要是肠上皮内淋巴细胞（iiel），它们嵌埋在肠上皮中，是体内最大的淋巴细胞群体之一。与身体其他部位的淋巴细胞相比，iiel具有独特的表型、发育和功能特性，反映了它们在维持肠上皮屏障中的关键作用。在这里，我们回顾了iels在支持正常健康中的生物学作用，以及它们的失调如何导致疾病。
The intestine is continuously exposed to commensal microorganisms, food and environmental agents, and also serves as a major portal of entry for many pathogens. A critical defense mechanism against microbial invasion in the intestine is the single layer of epithelial cells that separates the gut lumen from the underlying tissues. The barrier function of the intestinal epithelium is supported by cells and soluble factors of the intestinal immune system. Chiefly among them are intestinal intraepithelial lymphocytes (iIELs), which are embedded in the intestinal epithelium, and represent one of the single largest populations of lymphocytes in the body. Compared with lymphocytes in other parts of the body, iIELs exhibit unique phenotypic, developmental and functional properties that reflect their key roles in maintaining the intestinal epithelial barrier. Here, we review the biology of iIELs in supporting normal health and how their dysregulation can contribute to disease.
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DOI：
10.1073/pnas.1010890108
发表时间：
2011-02-22
影响因子：
11.1
作者：
Barbee, Susannah D.;Woodward, Martin J.;Hayday, Adrian C.
通讯作者：
Hayday, Adrian C.
影响因子：
32.4
作者：
Ettersperger, Julien;Montcuquet, Nicolas;Meresse, Bertrand
通讯作者：
Meresse, Bertrand
影响因子：
64.5
作者：
Barros, Rafael Di Marco;Roberts, Natalie A.;Dart, Robin J.;Vantourout, Pierre;Jandke, Anett;Nussbaumer, Oliver;Deban, Livija;Cipolat, Sara;Hart, Rosie;Iannitto, Maria Luisa;Laing, Adam;Spencer-Dene, Bradley;East, Philip;Gibbons, Deena;Irving, Peter M.;Pereira, Pablo;Steinhoff, Ulrich;Hayday, Adrian
通讯作者：
Hayday, Adrian
影响因子：
29.4
作者：
Edelblum KL;Singh G;Odenwald MA;Lingaraju A;El Bissati K;McLeod R;Sperling AI;Turner JR
通讯作者：
Turner JR
影响因子：
4.4
作者：
Denning, Timothy L.;Granger, Steve;Kronenberg, Mitchell
通讯作者：
Kronenberg, Mitchell