Enterohemorrhagic E. coli (EHEC) pathogenesis.
Enterohemorrhagic E. coli (EHEC) pathogenesis.
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DOI：
10.3389/fcimb.2012.00090
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发表时间：
2012
影响因子：
5.7
通讯作者：
Sperandio V
中科院分区：
文献类型：
--
作者：
Nguyen Y;Sperandio V
肠出血性大肠杆菌（EHEC）血清型O157：H7是一种引起世界范围内出血性腹泻和溶血性尿毒综合征（HUS）暴发的人类病原体。传统的抗菌剂在EHEC中引发SOS反应，促进强效滋贺毒素的释放，该毒素是与EHEC感染相关的大部分发病率和死亡率的原因。牛是肠出血性大肠杆菌的天然宿主，大约75%的肠出血性大肠杆菌爆发与食用受污染的牛源性产品有关。这篇综述将讨论肠出血性大肠杆菌如何在人类中引起疾病，但在成年反刍动物中无症状。它还将分析EHEC通过牛胃肠道（GI）时所利用的因素，这些因素允许EHEC通过远端胃的酸性环境存活，并最终定植在直肠肛门连接处（RAJ）。了解肠出血性大肠杆菌在牛中存活和定植的关键因素，将有助于制定替代战略，以防止肠出血性大肠杆菌排入环境和随后的人类感染。
Enterohemorrhagic Escherichia coli (EHEC) serotype O157:H7 is a human pathogen responsible for outbreaks of bloody diarrhea and hemolytic uremic syndrome (HUS) worldwide. Conventional antimicrobials trigger an SOS response in EHEC that promotes the release of the potent Shiga toxin that is responsible for much of the morbidity and mortality associated with EHEC infection. Cattle are a natural reservoir of EHEC, and approximately 75% of EHEC outbreaks are linked to the consumption of contaminated bovine-derived products. This review will discuss how EHEC causes disease in humans but is asymptomatic in adult ruminants. It will also analyze factors utilized by EHEC as it travels through the bovine gastrointestinal (GI) tract that allow for its survival through the acidic environment of the distal stomachs, and for its ultimate colonization in the recto-anal junction (RAJ). Understanding the factors crucial for EHEC survival and colonization in cattle will aid in the development of alternative strategies to prevent EHEC shedding into the environment and consequent human infection.
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影响因子：
3.1
作者：
DeanNystrom, EA;Bosworth, BT;Moon, HW
通讯作者：
Moon, HW
影响因子：
3.1
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Moon, HW
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4.4
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影响因子：
3.2
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影响因子：
39.2
作者：
Cody, SH;Glynn, MK;Vugia, DJ
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Vugia, DJ