RGS2: a multifunctional regulator of G-protein signaling
RGS2: a multifunctional regulator of G-protein signaling
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DOI：
10.1016/s1357-2725(01)00141-8
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发表时间：
2002-05-01
影响因子：
4
通讯作者：
Sinnarajah, S
中科院分区：
文献类型：
--
作者：
Kehrl, JH;Sinnarajah, S
G蛋白信号传导（RGS）蛋白的调节剂增强某些异源三聚体G蛋白α亚基将GTP水解为GDP的内在速率，从而限制α亚基激活下游效应物的持续时间。这种活性将它们定义为GT3活化蛋白（GAP）。与其他RGS蛋白一样，RGS2具有120个氨基酸的RGS结构域，其介导其GAP活性。此外，RGS2与RGS4和RGS16共享N端膜靶向结构域。存在于许多细胞类型中。RGS2表达受到高度调节。功能上的。RGS2阻断Gqalpha介导的信号传导，这一发现与其有效的Gqalpha GAP活性一致。令人惊讶的是，RGS2抑制Gs向某些腺苷酸环化酶的信号传导。与其他RGS蛋白一样，RGS2缺乏Gsalpha GAP活性，但它直接抑制几种腺苷酸环化酶同工型的活性。RGS2在小鼠中的靶向突变损害抗病毒免疫，增加焦虑水平，并改变海马CA1神经元的突触发育。RGS2已经成为一种多功能的RGS蛋白，调节多种G蛋白连接的信号通路。出版社：Elsevier Science Ltd
Regulators of G-protein signaling (RGS) proteins enhance the intrinsic rate at which certain heterotrimeric G-protein alpha-subunits hydrolyze GTP to GDP, thereby limiting the duration that alpha-subunits activate downstream effectors. This activity defines them as GTPase activating proteins (GAPs'). As do other RGS proteins RGS2 possesses a 120 ammo acid RGS domain, which mediates its GAP activity. In addition, RGS2 shares an N-terminal membrane targeting domain with RGS4 and RGS16. Found in many cell types. RGS2 expression is highly regulated. Functionally. RGS2 blocks Gqalpha-mediated signaling, a finding consistent with its potent Gqalpha GAP activity. Surprisingly, RGS2 inhibits Gs signaling to certain adenylyl cyclases. Like other RGS proteins, RGS2 lacks Gsalpha GAP activity, however it directly inhibits the activity of several adenylyl cyclase isoforms. Targeted mutation of RGS2 in mice impairs anti-viral immunity, increases anxiety levels, and alters synaptic development in hippocampal CA1 neurons. RGS2 has emerged as a multifunctional RGS protein that regulates multiple G-protein linked signaling pathways. Published by Elsevier Science Ltd.