Advanced Lung Cancer Inflammation Index Predicts Outcomes of Patients With Colorectal Cancer After Surgical Resection
Advanced Lung Cancer Inflammation Index Predicts Outcomes of Patients With Colorectal Cancer After Surgical Resection
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DOI：
10.1097/dcr.0000000000001658
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发表时间：
2020-09-01
影响因子：
3.9
通讯作者：
Kusunoki, Masato
中科院分区：
文献类型：
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作者：
Kusunoki, Kurando;Toiyama, Yuji;Kusunoki, Masato
背景技术背景：晚期肺癌炎症指数被认为是恶性肿瘤患者临床结局的有用预后生物标志物。然而，晚期肺癌指数对结直肠癌患者手术切除的预后价值尚不清楚。目的：在本研究中，我们评估了晚期肺癌指数对结直肠癌患者的预后价值。设计：回顾性评估了获得的结直肠癌患者的资料，以阐明晚期肺癌指数的临床相关性。我们在一个单一的专家中心进行了这项研究。患者：我们在这项回顾性研究中纳入了298例接受手术切除的结直肠癌患者。主要观察指标：主要结局是直肠癌患者中晚期肺癌指数的临床相关性。低状态的晚期肺癌指数与未分化的组织学显著相关（p= 0.004）、T分期进展（p< 0.001）、初次手术的R1/R2切除（p= 0.004）和远处转移（p< 0.001）。多变量分析显示，低晚期肺癌指数状态是结直肠癌患者总生存期（HR = 3.21（95%CI，1.97-5.19）;p< 0.001）和无病生存期（HR = 2.13（95%CI，1.23-3.63）;p= 0.008）的独立预后因素。此外，晚期肺癌指数的临床负担在性别之间是一致的，其预后价值在临床相关的III期结直肠癌患者中得到了验证。局限性：本研究有几个局限性，包括回顾性观察和来自单一机构的日本患者样本量小。晚期肺癌指数可能是结直肠癌手术切除患者临床结局的一个有用的预后指标。
BACKGROUND: The advanced lung cancer inflammation index is considered a useful prognostic biomarker of clinical outcomes in patients with malignancies. However, the prognostic value of the advanced lung cancer index in patients with colorectal cancer who underwent surgical resection remains unclear.OBJECTIVE: In this study, we evaluated the prognostic value of the advanced lung cancer index in patients with colorectal cancer.DESIGN: Prospectively obtained data of patients with colorectal cancer were retrospectively evaluated to clarify the clinical relevance of the advanced lung cancer index.SETTINGS: We conducted this study at a single expert center.PATIENTS: We enrolled 298 patients with colorectal cancer who underwent surgical resection in this retrospective study.MAIN OUTCOME MEASURES: The primary outcome was the clinical relevance of the advanced lung cancer index in patients with rectal cancer.RESULTS: Low status of advanced lung cancer index was significantly correlated with undifferentiated histology (p= 0.004), T stage progression (p< 0.001), R1/R2 resection for primary surgery (p= 0.004), and distant metastasis (p< 0.001). Multivariate analysis showed that low advanced lung cancer index status was an independent prognostic factor for both overall survival (HR = 3.21 (95% CI, 1.97-5.19);p< 0.001) and disease-free survival (HR = 2.13 (95% CI, 1.23-3.63);p= 0.008) in patients with colorectal cancer. Furthermore, the clinical burden of the advanced lung cancer index was consistent between sexes, and its prognostic value was verified in patients with clinically relevant stage III colorectal cancer.LIMITATIONS: The present study had several limitations, including retrospective observation and a small sample size of Japanese patients from a single institution.CONCLUSIONS: The advanced lung cancer index could be a useful prognostic indicator of clinical outcomes in patients who underwent surgical resection for colorectal cancer.