Actigraphy-derived rest--activity rhythms are associated with nocturnal blood pressure in young women.
Actigraphy-derived rest--activity rhythms are associated with nocturnal blood pressure in young women.
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DOI：
10.1097/hjh.0000000000002966
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发表时间：
2021-12-01
影响因子：
4.9
通讯作者：
Witman MA
中科院分区：
文献类型：
--
作者：
Hoopes EK;Patterson F;Berube FR;D'Agata MN;Brewer B;Malone SK;Farquhar WB;Witman MA
在实验研究中，生活方式行为和内源性昼夜节律之间的失调与夜间血压（BP）升高有关;然而，对自由生活（即，非实验室）昼夜节律紊乱和夜间BP。此外，昼夜节律紊乱的性别特异性心血管影响尚不清楚。研究男性和女性年轻人的静息-活动节律（RAR）（一种基于场的昼夜节律破坏估计）与夜间BP特征之间的相关性。50名参与者（20± 1岁; 20男性/30女性）在14天腕动记录后接受24小时动态血压监测。RAR变量的日间稳定性（IS; RAR的日间一致性）、日内变异性（IV; RAR的日内片段）和相对振幅（RA;峰与谷活动之间的差异）来自体动记录仪。生成平均夜间收缩压（SBP）、舒张压（DBP）和SBP下降的多变量回归模型，以检验与RAR变量的主要相关性以及性别X RAR相互作用。日间血压、种族、体重指数、体力活动、睡眠时间、酒精、咖啡因和钠摄入量被视为协变量。在整个样本中，未发现RAR与夜间血压特征之间存在主要关联，性别与RAR相互作用，在女性中，较高的IS（B=−5.39，95% CI=−10.04，−0.73，p=0.024）和RA（B=−4.78，95% CI=−9.22，−0.34，p=0.036）均与较低的夜间SBP相关。夜间BP的性别分层多变量模型也显示了IS和RA与女性SBP下降之间的相关性（所有p≤0.01）。在男性中没有明显的相关性。一致且高振幅的RAR与年轻女性成年人的夜间BP特征有利相关。
Misalignment between lifestyle behaviors and endogenous circadian rhythms is associated with elevated nocturnal blood pressure (BP) in experimental studies; however, less is known about free-living (i.e., non-laboratory) circadian disruption and nocturnal BP. Additionally, sex-specific cardiovascular implications of circadian disruption are unclear. To examine the associations between rest-activity rhythms (RAR), a field-based estimate of circadian disruption, and nocturnal BP characteristics in male and female young adults. Fifty participants (20±1y; 20M/30F) underwent 24-h ambulatory BP monitoring following 14-days of wrist actigraphy. RAR variables of interdaily stability (IS; day-to-day consistency in RAR), intradaily variability (IV; within-day fragmentation of RAR), and relative amplitude (RA; difference between peak vs. trough activity) were derived from actigraphy. Multivariable regression models of mean nocturnal systolic BP (SBP), diastolic BP (DBP), and SBP dipping were generated to test main associations with RAR variables, and sex X RAR interactions. Daytime BP, race, body mass index, physical activity, sleep duration, alcohol, caffeine, and sodium intake were considered as covariates. In the full sample, no main associations between RAR and nocturnal BP characteristics were found. Sex interacted with RAR such that in females, higher IS (B=−5.39, 95% CI=−10.04, −0.73, p=0.024) and RA (B=−4.78, 95% CI=−9.22, −0.34, p=0.036) were both associated with lower nocturnal SBP. Sex-stratified multivariable models of nocturnal BP also revealed associations between IS and RA with SBP dipping in females (all p≤0.01). No associations were apparent in males. Consistent and high-amplitude RAR are favorably associated with nocturnal BP characteristics in young female adults.