Multivariate analysis of TU wave complex on electrocardiogram in Andersen-Tawil syndrome with KCNJ2 mutations
Multivariate analysis of TU wave complex on electrocardiogram in Andersen-Tawil syndrome with KCNJ2 mutations
复制标题
DOI：
10.1111/anec.12721
复制
发表时间：
2019-11-14
影响因子：
1.9
通讯作者：
Horie, Minoru
中科院分区：
文献类型：
--
作者：
Horigome, Hitoshi;Ishikawa, Yasuhiro;Horie, Minoru
背景ATS 1的TU波复合体与健康人的TU波复合体之间的确切差异仍有待研究。我们试图用高频心电图（ECG）数据来描述Andersen-Tawil综合征1型（ATS 1）的TU波复合体。方法采用2kHz心电放大器记录13例KCNJ 2突变阳性的ATS 1患者（ATS 1组）和年龄匹配的健康人（对照组）的心电图。测量常规心电图参数，并对TU波群进行主成分分析（PCA）和独立成分分析（伊卡）。结果从T峰到U峰的时间（Tp）、从底部到U峰的时间（B）和从B到U端的时间（BUe，U持续时间）（0.232 +/- 0.018 vs. 0.165 +/- 0.017，p <0.0001），其中B是T波和U波之间的最低点，ATS 1组均长于对照组。多因素Logistic回归分析显示BUe能完全区分两组。ATS 1组的PCA比率显著大于对照组（26.5 +/- 12.3 vs. 10.4 +/- 6.2，p = .0005）。伊卡显示1或2个U波特异性独立成分（IC），仅包括ATS 1中的U波，而对照组中的U波由一些IC组成，这些IC也包括T波。结论U波相关的时间参数，特别是BUe，和U波特异性IC的存在，在伊卡中提取，是有用的区分U波在ATS 1和健康人。
Background The exact differences between the TU wave complex of ATS1 and that of healthy individuals remain to be investigated. We sought to characterize the TU wave complex of Andersen-Tawil syndrome type 1 (ATS1) using high frequency electrocardiogram (ECG) data. Methods Electrocardiograms were recorded as time series data with a 2 kHz frequency ECG amplifier in 13 patients with ATS1 (positive for KCNJ2 mutation, ATS1 group) and age-matched healthy individuals (control group). Conventional ECG parameters were measured, and principal component analysis (PCA) and independent component analysis (ICA) were applied to the TU wave complex. Results Time from T peak (Tp) to U peak (Up), time from bottom (B) to Up, and time from B to U end (BUe, U duration) (0.232 +/- 0.018 vs. 0.165 +/- 0.017, p < .0001), where B is the lowest point between T and U waves, were all longer in the ATS1 group than the control group. Multivariate logistic regression analysis revealed that BUe could completely differentiate the two groups. PCA ratios in the ATS1 group were significantly larger than the control group (26.5 +/- 12.3 vs. 10.4 +/- 6.2, p = .0005). ICA revealed 1 or 2 U-wave-specific independent components (ICs) that exclusively comprise the U wave in ATS1, whereas U waves in the control group were composed of some ICs that also comprised T waves. Conclusions U-wave-related temporal parameters, particularly BUe, and the existence of U-wave-specific ICs, extracted in the ICA, are useful for differentiation of U waves in ATS1 from those in healthy individuals.